绒毛膜促性腺激素及其游离β亚单位对不良妊娠的诊断价值

摘要

Objective To explore the diagnostic value of β‐human chorionic gonadotropin (β‐HCG) and its free β‐subunit (fβ‐HCG) of adverse pregnancy .Methods Chemiluminescence technique was used for the detection of serum levels ofβ‐HCG ,fβ‐HCG and progesterone in women with early adverse pregnancy (threatened abortion group ,missed abortion group and ectopic pregnancy group) and normal pregnant women (control group) ,respectively .The 48 h doubling rate ofβ‐HCG of each group was calculated . And the results were analyzed .Results Comparing with threatened abortion group ,there were significant differences in the levels of β‐HCG ,fβ‐HCG ,progesterone and doubling rate both of missed abortion group and ectopic pregnancy group (P<0 .05) .How‐ever ,there was no difference in these indicators between missed abortion group and ectopic pregnancy group ( P> 0 .05 ) . Conclusion T he changes of β‐HCG and fβ‐HCG can reflect adverse pregnancy .%目的：探讨β绒毛膜促性腺激素（β‐HCG）及其游离β亚单位（fβ‐HCG）在不良妊娠中的诊断价值。方法运用化学发光分析技术分别检测早期不良妊娠患者（先兆流产组、稽留流产组、异位妊娠组）及正常妊娠孕妇（对照组）的血清β‐HCG、fβ‐HCG、黄体酮水平，计算各组48h后β‐HCG的倍增率，对结果进行分析。结果与先兆流产组相比较，稽留流产组和异位妊娠组的β‐HCG、fβ‐HCG、黄体酮水平及β‐HCG倍增率差异均有统计学意义（P＜0．05）。稽留流产组与异位妊娠组之间各指标差异则无统计学意义（P＞0．05）。结论β‐HCG和fβ‐HCG水平变化可反映不良妊娠。