目的:探讨慢性肾脏病(CKD)患者不同时期血清铁蛋白(SF)和甲状旁腺素(PTH)的变化特点与血β2-微球蛋白(β2-MG)的相关性。方法测定不同肾功能时期 SF、PTH 和β2-MG 水平,分别与对照组比较,并将各期 SF、PTH 和β2-MG 水平进行相关性分析。结果代偿组患者 SF、PTH 和β2-MG 水平与对照组比较差异无统计学意义(P >0.05),而失代偿组、肾功能衰竭组和尿毒症组与对照组比较差异有统计学意义(P <0.05)。相关分析显示,145例患者 PTH 与β2-MG 呈正相关(r=0.92,P <0.05),SF 与β2-MG 亦呈正相关(r=0.92,P <0.05)。结论检测血清 PTH、SF 及β2-MG 水平对了解慢性肾脏病的病情发展和预后判断均有重要的临床价值。%Objective To investigate the change characteristics of serum ferritin(SF)and parathormone (PTH)levels in differ-ent stages of chronic kidney disease(CKD)and their correlation with serum beta 2-microglobulin(β2-MG).Methods The levels of serum PTH,SF andβ2-MG in different stages of CKD were detected and the detection results were compared with those in the con-trol group.The correlation between serum SF and PTH withβ2-MG in each stage of CKD was analyzed.Results The level of ser-um PTH,SF andβ2-MG in the compensation group had no statistical difference compared with the control group (P >0.05),while which had statistical differences among the decompensation group,renal failure group and uremia group (P <0.05)The correlation analysis showed that serum PTH was positively correlated with serumβ2-MG in 145 cases(r=0.92,P <0.05),and the serum SF level was also positively correlated with serumβ2-MG level(r=0.92,P <0.05).Conclusion Detecting serum PTH,SF andβ2-MG levels possesses the important clinical significance for understanding CKD condition and prognosis.
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