慢性肾功能不全患者贫血代谢物检测的临床意义

摘要

Objective To investigate the clinical value of serum iron(Fe),total iron binding capacity(TIBC),serum ferritin(SF), folic acid(FA)and vitamin 12(ViB12 )in the diagnosis and treatment of chronic renal failure(CRF).Methods Fasting blood sam-ples were collected from 72 patients with CRF and 83 normal controls.Then the serum SF,ViB12 and FA contents were measured by the ARCHITECT i2000SR fully automatic chemiluminescence immunoassay analyzer;serum Fe and TIBC were detected by the VITORS FS 5.1 dry biochemical analyzer;RBC,HGB,HCT and MCV were analyzed by the Mindray BC-6800 complete automated blood counter.The detection results were performed the statistical analysis by the SPSS16.0 software.Results The levels of TIBC,RBC,HGB and HCT in the CRF patients were significantly lower than those in the control group(P <0.05);while the SF and ViB12 levels were significantly higher than those in the control group;serum Fe and MCV had no statistical difference compared with the control group(P >0.05);the FA level in the female patients was lower than that in the control group,but which in the male patients had no statistical differences compared with the control group(P >0.05).Conclusion The indexes of anemia associat-ed metabolin in the CRF patients can provide certain reference value for the diagnosis and treatment of chronic renal fail and has cer-tain guidance significance for correcting anemia caused by renal insufficiency.%目的：探讨慢性肾功能不全（CRF）患者血清铁（Fe）、总铁结合力（TIBC）、铁蛋白（SF）、叶酸（FA）和维生素 B12（ViB12）检测的临床诊疗价值。方法 ARCHITECT i2000SR 全自动免疫化学发光分析仪检测72例 CRF 患者和83例健康对照人群血清 SF、FA 和 ViB12水平；VITROS FS 5．1干式生化分析仪检测血清 Fe 和 TIBC 水平；Mindray BC-6800五分类血常规分析仪检测红细胞（RBC）、血红蛋白（HGB）、红细胞压积（HCT）和红细胞平均体积（MCV）。所有检测结果采用 SPSS16．0统计学软件进行统计分析。结果 CRF 患者 TIBC、RBC、HGB 和 HCT 均明显低于对照组（P ＜0．05）；SF 和 ViB12水平明显高于对照组（P ＜0．05）；血清 Fe 和 MCV 与对照组比较差异无统计学意义（P ＞0．05）；女性患者 FA 水平低于对照组（P ＜0．05），而男性患者FA 水平与对照组比较差异无统计学意义（P ＞0．05）。结论 CRF 患者体内贫血相关代谢物指标可为疾病的诊断和治疗提供一定的参考价值，对纠正肾功能不全引起的贫血有一定的指导意义。