糖尿病足合并铜绿假单胞菌感染的危险因素分析

摘要

Objective To explore the risk factors of Pseudomonas aeruginosa infection in diabetic foot .Methods 136 patients with diabetic foot were divided into infection group (n=12) and control group(n=124) according to whether Pseudomonas aerugi-nosa infection existed .Their age ,gender ,body mass index (BMI) and complications were recorded ,and their hemoglobin ,fasting plasma glucose (FPG ) ,two hours postprandial blood glucose (2hPBG ) ,glycosylated hemoglobin A1c (GHbA1c) ,cholesterol , triglycerides ,low density lipid(LDL) ,high density lipid(HDL) ,serum albumin(SALB) were detected .Logistic regression analysis was employed to analyze the risk factors of Pseudomonas aeruginosa infection .Results Incidence of Pseudomonas aeruginosa infec-tion in diabetic foot was 8 .8% .Among them ,the infection incidences of elderly patients and patients with diabetic nephropathy were 11 .6% and 12 .7% ,respectively .Univariate analysis showed that male ,advanced age ,BMI ,duration of diabetes ,history of heart disease ,diabetic nephropathy ,FPG ,2hPBG ,GHbA1c ,low hemoglobin and low SALB were associated risk factors of Pseudomonas aeruginosa infection(P<0 .05) .After correction of confounding factors such as male ,BMI ,history of heart disease ,2hPBG and low hemoglobin ,advanced age ,duration of diabetes ,diabetic nephropathy ,GHbA1c and low SALB were independent risk factors for Pseudomonas aeruginosa infection(P<0 .05) .Conclusion Advanced age ,duration of diabetes ,diabetic nephropathy ,GHbA1c and low SALB are independent risk factors for Pseudomonas aeruginosa infection .%目的：探讨糖尿病足合并铜绿假单胞菌感染的危险因素。方法将136例糖尿病足患者根据有无铜绿假单胞菌感染分为感染组（n＝12）与对照组（n＝124）。记录糖尿病足患者的年龄、性别、身体质量指数（BMI）及合并症；检测其血红蛋白、空腹血浆葡萄糖（FPG）、餐后2小时血糖（2hPBG）、糖化血红蛋白（GHbA1c）、胆固醇、三酰甘油、低密度脂蛋白（LDL）、高密度脂蛋白（HDL ）、血清清蛋白（SALB）。铜绿假单胞菌感染的危险因素采用Logistic多因素回归分析。结果糖尿病足铜绿假单胞菌感染发生率为8．8％，其中，老年和糖尿病肾病患者感染发生率分别为11．6％和12．7％；单因素分析显示，男性、高龄、BM I、糖尿病病程、心脏病史、糖尿病肾病、FPG、2hPBG、GHbA1c、低血红蛋白及低SALB是铜绿假单孢感染的相关危险因素（P＜0．05）；校正男性、BMI、心脏病史、2hPBG及低红血蛋白后，高龄、糖尿病病程、糖尿病肾病、GHbA1c及低SALB是铜绿假单胞菌感染的独立危险因素（P＜0．05）。结论高龄、糖尿病病程、糖尿病肾病、GHbA1c及低SALB是糖尿病足铜绿假单胞菌感染的独立危险因素。