克拉玛依地区维吾尔族和汉族健康成人T 淋巴细胞亚群绝对计数及CD4＋／CD8＋比值研究

摘要

目的：调查克拉玛依地区维吾尔族和汉族健康成人的CD3＋、CD4＋、CD8＋计数及CD4＋／CD8＋比值，为该地区相关疾病的诊断、治疗及预后指导提供依据。方法选取181例健康成人，留取静脉全血，采用细胞芯片定量检测技术检测CD3＋、CD4＋、CD8＋细胞，比较维吾尔族与汉族健康成人 CD3＋、CD4＋、CD8＋绝对值和 CD4＋／CD8＋比值的参考范围。结果除了CD8＋计数均值和CD4＋／CD8＋比值在两族间差异无统计学意义（ P＞0．05）外，CD3＋、CD4＋计数均值在维吾尔族和汉族间差异均有统计学意义（P＜0．05）。结论 CD4＋诊疗标准的设立应重视地域和生活环境的差异，按种族设立不同正常参考值范围对诊断疾病有较大意义。%Objective To built the reference range of peripheral blood T-lymphocyte subsets including CD3+ ,CD4+ ,CD8+ and CD4+ /CD8+ ratio in healthy adults of Ugyur and Han nationalities and to provide basis for the diagnosis ,therapy and prognosis of disease .Methods A total of 181 blood samples were collected from healthy adults .The cell chip quantitative detection technology was used to detect CD3+ ,CD4+ and CD8+ ,CD3+ ,CD4+ absolute value ,CD8+ and CD4+ /CD8+ ratio were compared between Ugyur and Han nationalities .Results CD8+ absolute counting and CD4+ /CD8+ ratio had no significant difference between Ugyur and Han nationalities(P>0 .05) ,while the CD3+ ,CD4+ absolute counting had significant difference(P<0 .05) .Conclusion The discrepancy of territory and living environment should be taken into account for building a reference values of CD4+ .