目的：探讨妊娠中晚期血清同型半胱氨酸（Hcy）、叶酸、维生素B12水平检测对妊娠高血压综合征（简称妊高征）患者的意义。方法选取2012年1月至2013年12月于该院分娩的孕妇76例。其中，38例为妊高征患者（妊高征组），38例为健康孕妇（健康孕妇组）。采集上述孕妇空腹静脉血，采用荧光偏振免疫分析法测定血清 Hcy水平，离子捕捉免疫分析法测定血清叶酸的水平，微粒子酶联免疫分析法测定维生素B12水平，并对两组孕妇的上述指标进行比较。结果妊高征组血清 Hcy水平比健康孕妇组高，差异有统计学意义（P＜0．05）；叶酸的水平比健康孕妇组低，差异有统计学意义（P＜0．05）。两组间血清维生素B12水平比较，差异无统计学意义（P＞0．05）。结论血清 Hcy、叶酸水平的检测有助于指导妊高征患者的治疗。%Objective To study the significance of homocysteine(Hcy) ,folic acid ,vitamin B12 detection in mid and late pregnancy for the the patients with pregnancy‐induced hypertension syndrome .Methods 76 women who gave birth in the hospital from Janu‐ary 2012 to December 2013 were enrolled in the study .38 of them were patients with pregnancy‐induced hypertension syndrome (pregnancy‐induced hypertension group) ,the other 38 were healthy pregnant women(normal pregnancy group) .Fasting venous blood of those pregnant women were collected and tested for Hcy ,folic acid ,and vitamin B12 concentrations by using fluorescence polarization immunoassay ,ion serum folate levels capture immunoassay and microparticle enzyme‐linked immunosorbent assay re‐spectively .Then the test results were compared between the two groups .Results The serum concentrations of Hcy in pregnancy‐induced hypertension group were higher than that in normal pregnancy group ,and the difference was pregnancy‐induced hyperten‐sion gourp statistically significant(P<0 .05) .The serum concentrations of folic acid in pregnancy‐induced hypertension gourp were lower than that in normal pregnancy group ,and the difference was statistically significant(P<0 .05) .The comparision of serum vi‐tamin B12 concentrations between the two groups showed no statistically significant difference(P>0 .05) .Conclusion The detection of serum Hcy and folic acid could help to guide the treatment of patients with pregnancy induced hypertension syndrome .
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