超敏C反应蛋白联合 N-端脑利钠肽前体在心力衰竭中的应用分析

摘要

Objective To explore the hypersensitive c‐reactive protein(hs‐CRP) combined N‐brain natriuretic peptide precursor application value in heart failure .Methods 50 cases of heart failure patients of our hospital as research object ,this group of patients as experimental group .In order to make the research more persuasive ,in addition to select 50 cases of healthy people as control group .Experimental group patients to standards as set by the u .s .New York heart association ,according to the grouping of 24 pa‐tients with rank Ⅱ ,Ⅲ level 15 patients ,11 patients with Ⅳ level .Using colloidal gold method of N‐terminal patients plasma brain natriuretic peptide precursor concentration and left ventricular ejection fraction ,the concentrations of plasma brain natriuretic pep‐tide precursor N‐end needs were determined and the concentration of the hospital for five days prior to admission .Measurement by scattering turbidimetry ,and also need the hs‐CRP serum levels .Results Compare two groups of measuring results were found that the experimental group than the control group of N‐the brain natriuretic peptide precursor level obviously higher ,and the left ven‐tricular ejection fraction was lower than the control group .For the hs‐CRP serum levels of the experimental group is significantly higher than the control group ,cardiac function classification as the increasing of the number of this gap is widening .At levels Ⅱ -Ⅳ obvious the differences between the three ,with statistical significance(P<0 .05) .Conclusion hs‐CRP and N‐brain natriuretic peptide precursor concentration can be as an important indicator of heart failure determination ,has united both in clinical can more effectively to diagnosis heart failure .hs‐CRP in combination with N‐terminal brain natriuretic peptide precursor obvious effects of application in heart failure ,is worth popularizing in clinical use .%目的：探究超敏C反应蛋白（hs‐CRP）联合N‐端脑利钠肽前体在心力衰竭中的应用价值。方法该院收治的50例心力衰竭患者为研究对象，将该组患者作为实验组。另外选取50例健康者作为对照组。将实验组患者以美国纽约心脏病协会制定的标准作为根据进行分级，其中Ⅱ级患者有24例，Ⅲ级患者有15例、Ⅳ级患者11例。采用胶体金法对患者血浆N‐端脑利钠肽前体浓度以及左室射血分数，在对血浆N‐端脑利钠肽前体浓度测定时需要分别测定入院前以及入院5d后的浓度。并且还需要采用散射比浊法，测量血清hs‐CRP水平。结果将两组的测量结果进行比较发现，实验组较对照组的N‐端脑利钠肽前体水平明显要高，而左室射血分数却要比对照组低许多。对于血清hs‐CRP水平实验组要明显高于对照组，随着心功能分级数的增大这种差距也随之拉大。在Ⅱ～Ⅳ级这三级之间的差异也比较明显，具有统计学意义（P＜0．05）。结论 hs‐CRP和N‐端脑利钠肽前体浓度都可以作为心力衰竭判定的一个重要的指标，在临床上将这两者联合可以更加有效地对心力衰竭进行诊断。hs‐CRP联合N‐端脑利钠肽前体在心力衰竭中的应用效果明显，值得在临床上推广使用。