尿微量蛋白和尿酶测定在过敏性紫癜患儿早期肾损伤中的临床意义

摘要

Objective To investigate the clinical significance of the urine micro albumin(MA)and urine enzyme detections in early renal injury in children with allergic purpura.Methods 120 patients with allergic purpura were chosen as the research sub-jects and divided into the early renal injury group and non-renal injury group according to whether having the renal injury.Contem-poraneous 40 healthy children were chosen as the healthy control group.The urine MA and urine enzyme levels were detected and compared among the various groups.Results MA was (17.5 ±3.8)mg/L in the study group,transferring(TRF)was (0.56 ± 0.34)mg/L,β2-MG was (0.35 ±0.07 )mg/L,NAG was (18.6 ±5.1 )U/g,which were significantly higher than those in the healthy control group,the differences were statistically significant (P <0.05 );in the early renal injury group,MA was (42.1 ± 21.3)mg/L,TRF was (1.65±0.54)mg/L,β2-MG was (0.43±0.06)mg/L and NAG was (23.1±5.12)U/L,which were signif-icantly higher than those in the non-renal injury group,the differences had statistically significance (P <0.05).Conclusion The de-tection of urine MA and urine enzyme can be used as the indexes for monitoring the early renal injury in children with allergic pur-pura,and is conducive to early discovery,in time intervention and reduce the occurrence of complications.%目的：探讨尿微量清蛋白（MA）和尿酶测定在过敏性紫癜患儿早期肾损伤中的临床意义。方法选取120例过敏性紫癜患者作为研究组，过敏性紫癜患儿根据有无肾功损害分为早期肾损伤组和无损伤组，另选取同期该院行健康查体的40例健康儿童作为健康对照组，分析比较各组间尿 MA 和尿酶水平。结果研究组患者的 MA 为（17．5±3．8）mg／L、转铁蛋白（TRF）为（0．56±0．34）mg／L、β2-微球蛋白为（β2-MG）为（0．35±0．07）mg／L、N-乙酰-B-D-氨基-葡萄糖苷酶（NAG）为（18．6±5．1） U／L，显著高于健康对照组，差异有统计学意义（P ＜0．05）；早期肾损伤组 MA（42．1±21．3）mg／L、TRF（1．65±0．54）mg／L、β2-MG（0．43±0．06）mg／L、NAG（23．1±5．12）U／L，显著高于无损伤组，差异有统计学意义（P ＜0．05）。结论尿 MA 和尿酶检测可以作为监测过敏性紫癜患儿早期肾损伤的指标，有利于早期发现、及时干预，减少并发症的发生。