Objective To investigate the detection value of thyrotropin receptor antibody(TRAb)in children with autoimmune thyroid disease.Methods During the January 2015 and October 2016,a total of 72 cases of children with autoimmune thyroid dis-ease admitted to our hospital were selected,including 36 cases of Graves disease as the Graves disease group,and 36 cases of Hashi-moto's thyroiditis as Hashimoto's thyroiditis group;36 cases of healthy children in this hospital at the same period were selected as the control group.Children in the Graves disease group and Hashimoto's thyroiditis group were taken routine treament,ane the changes of the serum TRAb level before the treatment and one year after the treatment between the two groups.The positive value range of TRAb level is more than 1.75 U/L,and the positive rate of serum TRAb level before the treatment and one year after the treatment was recorded in the two groups.Results Before treatment,TRAb level of the Graves disease group[(12.79 ± 6.38)U/L]was higher than those in Hashimoto's thyroiditis group[(2.03 ± 0.29)U/L]and the control group[(0.85 ± 0.23)U/L],and the difference was statistically significant(P<0.05);TRAb level of the Hashimoto's thyroiditis group[(2.03 ± 0.29)U/L]was significantly higher than that of the control group[(0.85 ± 0.23)U/L],(P<0.05).After treatment:TRAb level of the Graves disease group[(9.36 ± 12.14)U/L]was significantly higher than those in Hashimoto's thyroiditis group[(1.78 ± 0.38)U/L]and the control group[(0.84 ± 0.29)IU/L],and the difference was statistically significant(P<0.05);TRAb level of the Hashimoto's thyroiditis group was significantly higher than the control group,and the difference was statistically significant(P<0.05).TRAb levels in patients with graves'disease and Hashimoto thyroiditis after treatment were significantly lower than those before treat-ment,and the difference was statistically significant(P<0.05).The positive rates of TRAb level in the Graves disease group before and after treatment were 100%,and the positive rate of TRAb level in Hashimoto's thyroiditis group after treatment(11.11%)de-creased in comparison with the one before treatment(22.22%),and the difference was statistically significant(P<0.05).Conclusion There is a significant change of TRAb level in children with autoimmune thyroid disease.Especially,the change of TRAb level in Graves disease before and after treatment may provide a reference for clinical diagnosis and prognosis evaluation of Graves disease.%目的 探讨儿童自身免疫甲状腺病促甲状腺素受体抗体(T RAb)测定的临床应用价值.方法 选择2015年1月至2016年10月该院收治的72例儿童自身免疫甲状腺病患儿,其中36例Graves病患儿作为Graves病组,36例桥本甲状腺炎患儿作为桥本甲状腺炎组;另选择同期在该院体检的健康儿童36例作为对照组.Graves病和桥本甲状腺炎患儿均进行常规治疗,观察两组患儿治疗前和治疗1年后血清TRAb水平变化.TRAb值阳性范围为>1.75 U/L,统计两组患儿治疗前和治疗1年后血清TRAb阳性率.结果 治疗前Graves病组TRAb[(12.79 ± 6.38)U/L]水平高于桥本甲状腺炎组[(2.03 ± 0.29)U/L]和对照组[(0.85 ± 0.23)U/L],差异有统计学意义(P<0.05);桥本甲状腺炎组 T RAb水平高于对照组,差异有统计学意义(P<0.05);治疗后Graves病组TRAb[(9.36 ± 12.14)U/L]水平高于桥本甲状腺炎组[(1.78 ± 0.38)U/L]和对照组[(0.84 ± 0.29)U/L],组间比较差异有统计学意义(P<0.05);桥本甲状腺炎组 T RAb水平显著高于对照组,组间比较差异有统计学意义(P<0.05);Graves病组和桥本甲状腺炎组治疗后TRAb水平均低于治疗前,差异有统计学意义(P<0.05);Graves病组治疗前后 TRAb阳性率均为100%,桥本甲状腺炎组治疗后TRAb阳性率(11.11%)较治疗前(22.22%)下降,治疗前后比较差异有统计学意义(P<0.05).结论 儿童自身免疫甲状腺病存在明显 TRAb指标变化,尤其是Graves病治疗前后 TRAb指标明显变化,可为Graves病临床诊断和预后评估提供一定参考依据.
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