Hcy、叶酸、PLT、MPV、PDW检测对反复性流产患者的意义

摘要

目的 评估反复性流产(RSA)患者的血小板功能,并探讨同型半胱氨酸(Hcy)、叶酸与血小板平均体积(MPV)、血小板分布宽度的相关性,评价以上指标在预测RS A中的应用价值.方法 患者组选取开封市中心医院RS A组共28例,健康妊娠组40例,对照组选取健康育龄妇女50例.检测项目为:外周血Hcy、叶酸、PL T、M PV、PDW.结果 患者组与正常妊娠组及对照组相比较,PLT、叶酸水平显著降低(P<0.01),Hcy、PDW、血小板平均体积(MPV)水平均增高(P<0.05);正常妊娠组和对照组相比较,各项指标比较差异无统计学意义(P>0.05).患者组血Hcy与PLT、叶酸呈负相关(P<0.05);正常妊娠组Hcy与叶酸呈负相关(P<0.05),其他指标间无明显相关性(P>0.05).结论 Hcy代谢异常及血小板参数改变及其相互作用可能与RSA有关,联合检测Hcy、叶酸及血小板参数等指标对RSA的早期诊断和治疗具有一定临床意义.%Objective To evaluate the platelet function in the patients with recurrent spontaneous abortion (RSA) ,to explore the correlations between Hcy and folic acid(FA)with mean platelet volume(MPV) and platelet distribution width(PDW) ,and to evalu-ate the application value of above indicators in predicting RSA .Methods Twenty-eight cases of RSA ,40 cases of healthy pregnancy and 50 healthy child-bearing women(control group) in our hospital were selected .The detection indicators included peripheral blood Hcy ,FA ,PLT ,MPV and PDW .Results The PLT and FA levels in the patients group were significantly lower compared with the normal pregnancy group and control group(P<0 .01) ,while the Hcy ,PDW and MPV were increased(P<0 .05);the various indica-tors had no statistically significant difference between the normal pregnancy group and control group (P>0 .05) .Blood Hcy was negatively correlated with PLT and FA ;Hcy and FA were negatively correlated in the normal pregnancy group ,other indicators had no obvious correlation(P>0 .05) .Conclusion The Hcy metabolism abnormality ,platelet parameter changes and their interactions may be related to RSA .The combined detection of Hcy ,FA and platelet parameters has a certain clinical significance to early diag-nosis and treatment of RSA .