骨保护素基因多态性与中国辽宁地区汉族人群大动脉粥样硬化性卒中风险无关

摘要

目的 探讨辽宁地区汉族人群中骨保护素(osteoprotegerin,OPG)基因rs3134069、rs2073617和rs2073618多态性与大动脉粥样硬化性卒中(large artery atherosclerotic stroke,LAA)发病风险的相关性.方法 采用病例对照研究设计,按照TOAST病因分型选取213例LAA患者作为病例组,197例同期健康体检者作为对照组.采用改良多重连接酶反应技术对rs3134069、rs2073617和rs2073618进行基因分型.采用多变量logistic回归分析确定基因多态性与LAA的独立相关性.结果 病例组OPG基因rs3134069、rs2073617和rs2073618基因型和等位基因分布频率均与对照组差异无统计学意义(P均＞0.05),显性模型和隐性模型分析亦显示差异无统计学意义(P均＞0.05).结论 OPG基因rs3134069、rs2073617和rs2073618多态性与辽宁地区汉族人群LAA易感性无显著相关性,各等位基因的存在不能构成LAA发病的危险因素.%Objective To investigate the correlation between the gene polymorphism of osteoprotegerin genes rs3134069,rs2073617 and rs2073618 and the onset risk of large artery atherosclerotic stroke (LAA) in the Han population in Liaoning,China.Methods Using the case-control study design,213 patients with LAA were selected as case group according to the TOAST etiology classification,and 197 health subjects in the same period were selected as control group.Rs3134069,rs2073617,and rs2073618 were genotyped using the modified multiplex ligase reaction technique.Multivariate logistic regression analysis was used to determine the independent correlation between gene polymorphism and LAA.Results There were no significant differences in the genotypes and alsle distribution frequencies of OPG genes rs3134069,rs2073617 and rs2073618 between the case group and the control group (all P ＞0.05).The dominant and recessive models also showed that there were no significant differences (all P＞0.05).Conclusion The polymorphisms of OPG genes rs3134069,rs2073617 and rs2073618 were not significantly associated with LAA susceptibility in Han population of Liaoning,China.The presence of each allele could not constitute a risk factor for the onset of LAA.