登革热疫苗的近期研究进展

摘要

登革热已成为世界上分布最广、发病最多的虫媒病毒病。人口增加和流动性增大加剧了登革病毒传播，对人类健康造成了严重威胁。目前尚无针对该病毒的疫苗上市，几种候选疫苗正处于临床试验阶段。此文就登革病毒的结构特征以及一些前景较好的登革热疫苗的研究状况做一综述。%Dengue fever has become the most widely distributed arbovirus disease with the largest incidence over the world .The increase of population and mobility contributes to the spread of dengue virus ,threatening human health severely .Currently ,no licensed vaccine for dengue virus is available , but several candidates have entered clinical trails .This review summarizes the structural characteristics of dengue virus ,and research status of some promising candidate vaccines .