RNA干扰技术在视网膜疾病治疗中的研究进展

摘要

RNA interference exists widely in animals, which can induce specific genetic sequence to silence by double -stranded RNA molecules at the mRNA level. As a kind of new methods of blocking gene expression, RNA interference technology has become increasingly mature and perfect, it has opened up a new approach of gene therapy. RNA interference can effectively prevent the formation of new vessels in retina, restrain the occurrence and development of the proliferative vitreous retinopathy, and induce apoptosis of retinoblastoma cells. The research progress of the RNA interference in the above retinopathy was summarized in this review.%RNA干扰(RNA interference,RNAi)是一种在动物中广泛存在的、通过双链 RNA 分子在mRNA水平上诱导特异性序列基因沉默的过程.作为一种阻断基因表达的新手段,RNAi技术日趋成熟完善,开辟了一条基因治疗的新途径.RNAi技术能够有效阻止视网膜新生血管的形成,抑制增生性玻璃体视网膜病变的发生和发展,诱导视网膜母细胞瘤细胞的凋亡.现将RNAi技术在上述视网膜病变中的研究进展作一综述.