翼状胬肉切除联合生物羊膜移植术后泪膜稳定性研究

摘要

AIM:To assess changes of tear film function in patients after pterygium excision combined with amniotic membrane transplantation. METHODS:Totally 126 patients with pterygium excision with amniotic membrane transplantation from January 2011 to November 2013 were entered in the study. The tear breakup time ( BUT) , the Schirmer I test ( SⅠt) and tear ferning test ( TFT ) were elevated in the patients before and after pterygium excision combined with amniotic membrane transplantation. The examnation times were 1d before surgey, 1wk, 1, 2mo after surgery. Operation eyes were studied group, while opposite healthy eyes as control group. RESULTS: Compared with the control group, BUT and TFT were significantly different in the eyes with pterygium (P0. 05). The results of BUT and TFT at 1mo after surgery in study group were significantly better than 1wk (P0. 05); The tear film stability in the study group at 1wk after surgery was still inferior to the control group (P0. 05). SⅠt results did not differ between the different examination times(P>0. 05). CONCLUSION:Tear film stability was broken in the eyes with pterygium. Pterygium excision combined with amniotic membrane transplantation can obviously restore the tear film function into normal state, and the tear film function could reach steady-state 1mo after surgery.%目的：评价翼状胬肉切除联合生物羊膜移植术后泪膜功能的改变。　　方法：该研究共纳入126例单眼翼状胬肉患者,就诊时间2011-01/2013-11,所有患者均行翼状胬肉切除联合生物羊膜移植术。分别于术前1 d；术后1 wk；1,2 mo行双眼泪膜功能检查,包括泪液分泌试验( Schirmer Ⅰ test,SⅠt)、泪膜破裂时间( break up time,BUT)、泪液羊齿状物试验(tear ferning test,TFT)。手术眼为研究组,对侧眼为对照组。　　结果：与对照组相比,研究组术前BUT, TFT均显著异常(P0.05)；研究组术后1mo 时 BUT,TFT 均明显优于术后1wk(P0.05)。研究组术后1wk 泪膜稳定性仍低于对照组(P0.05)。 SⅠt试验结果显示两组之间各个时间点比较无显著差异(P均>0.05)。　　结论：翼状胬肉术前存在明显的泪膜稳定性异常；翼状胬肉切除联合生物羊膜移植可以显著改善术后泪膜功能,术后1 mo时达到稳态。