炎症因子在青光眼中的作用研究进展

摘要

青光眼是一组具有特征性视神经损害和视野缺损的疾病，病理性眼压增高是其危险因素。青光眼是受多种基因的相互作用以及环境因素影响的疾病，近年来研究表明，炎症也可能参与青光眼的发病机制，大量研究已证实，结缔组织生长因子（ connective tissue growth factor， CTGF）、肿瘤坏死因子－α（ tumor necrosis factor－α， TNF－α）、白细胞介素（ interleukins，ILs）、核转录因子－kappa B （nuclear factor－kappa B，NF－κB）等多种细胞因子，在青光眼患者眼内房水中高表达，表明这些细胞因子与青光眼的发病机制有紧密的联系，本文就近年来有关炎症因子与青光眼关系的研究进展作一综述。%?Glaucomais a group of diseases characterized by optic nerve damage and visual field defect, and pathological high intraocular pressure is a risk factor for glaucoma. Glaucoma is affected by the interaction of multiple genes and environmental factors, and inflammation may be involved in the pathogenesis of glaucoma.A great deal of studies have confirmed that high expression of connective tissue growth factor ( CTGF) , tumor necrosis factor-α( TNF-α) , interleukins ( ILs ) , nuclear factor-kappa B( NF-κB) and various cytokines in the aqueous humor of patients with glaucoma, which have a close correlation with pathogenesis of glaucoma.This article reviews the progress of inflammatory cytokines and their relationship with glaucoma.