贞芪扶正颗粒联合抗结核药治疗肺结核临床疗效及对T淋巴细胞亚群的影响

摘要

目的:探讨贞芪扶正颗粒联合抗结核药对肺结核患者的临床疗效及对血浆中T淋巴细胞亚群的影响.方法:选择符合纳入标准的100例肺结核患者随机分为联合组及对照组,联合组给予贞芪扶正颗粒联合抗结核药干预治疗,对照组给予常规抗结核药物治疗,观察半年.比较两组患者痰菌阴转率及T淋巴细胞亚群的变化.结果:联合组的总有效率(94.0%)显著高于对照组(86.0%)(P<0.01);联合组的痰培养转阴率明显高于对照组(P<0.01);联合组患者的CD+3、CD+4及CD+4/CD+8的比值显著高于对照组(P<0.01),CD+8的含量显著低于对照组(P<0.01);联合组的不良反应率显著低于对照组(P<0.01).结论:贞芪扶正颗粒联合抗结核药具有显著提高肺结核患者的T淋巴细胞亚群,改善患者的免疫状态,降低长期服用抗结核药的不良反应.%Objective:To investigate the clinical effect of Zhenqi Fuzheng Granule combined with anti-tuberculosis drugs in the treatment of 100 cases of pulmonary tuberculosis,and to explore the difference of T-lymphocyte subsets changes in plasma.Methods:100 patients with pulmonary tuberculosis were randomly divided into the control group and the combination group.The control group was intervened merely by conventional anti-tuberculosis drugs,and the combination group was treated with Zhenqi Fuzheng granule combined with anti-tuberculosis drugs.The sputum negative conversion rate,and changes of T-lymphocyte subsets were compared between the two groups after six months.Results:The total effective rate in the combination group was 94.0%,which was significantly higher than 86.0% in the control group (P<0.01).The contents of CD+3 and CD+4,and the ratio of CD+4/CD+8 in the combination group were significantly higher than those in the control group(P<0.01);however,the content of CD+8 in the combiation group was significantly lower than that in the control group (P<0.01);the adverse reaction in the combination group was significantly less than that in the control group(P<0.01).Conclusion:Zhenqi Fuzheng Granule combined with anti-tuberculosis drugs can significantly increase the T-lymphocyte subsets,improve the immune status and reduce the adverse reactions of long-term use of anti-tuberculosis drugs.