粒细胞集落刺激因子治疗慢加急性肝衰竭疗效荟萃分析

摘要

目的 评价粒细胞集落刺激因子治疗慢加急性肝衰竭的疗效.方法 计算机检索Cochrane图书馆(1970-2018)、EMBASE(1966-2018)、Pubmed(1966-2018)和中国生物医学文献资料库(1978-2018),查找粒细胞集落刺激因子治疗慢加急性肝衰竭随机对照试验的相关文献.由2名研究者独立选择文献、提取资料和评估方法学质量,采用Cochrane协作网提供的RevMan 5.3软件进行统计分析.结果 共有3篇文献,包括201例患者纳入本研究.荟萃分析结果显示:与安慰剂/空白对照组比较,使用粒细胞集落刺激因子治疗可以有效提高慢加急性肝衰竭患者生存率(RR=1.72,95%CI:1.25～2.37,P=0.0009).结论 粒细胞集落刺激因子可以有效提高慢加急性肝衰竭患者生存率.%Objective To evaluate the effect of granulocyte-colony stimulating factor (G-CSF) on acute-on-chronic liver failure (ACLF). Methods The literatures and corresponding references of randomized controlled trials on G-CSF in the treatment of ACLF were searched from Cochrane Library (from 1970 to 2018), EMBASE (from 1966 to 2018), Pubmed (from 1966 to 2018) and China Biology Medicine disc (from 1978 to 2018). Selection of literatures, data extraction and methodological quality assessment were separately performed by 2 researchers. The software RevMan 5.3 of Cochrane Collaboration was used for statistical analysis. Results A total of 3 trails, including 201 patients were enrolled in this study. Meta analysis results showed that G-CSF could effectively improve the survival rate of ACLF patients compared with placebo/blank controls (RR=1.72, 95%CI: 1.25 ～ 2.37, P=0.0009). Conclusions G-CSF can effectively improve the survival rate of ACLF patients.