未接受HAART的HIV/AIDS患者血清隐球菌抗原阳性率调查

摘要

Objective To investigate the positive rates of serum cryptococcal antigen in HIV/AIDS patients without initiating highly active antiretroviral therapy (HAART). Methods CD4+ T lymphocyte counts and the positive rates of serum cryptococcal antigen of 77 HIV/AIDS patients without initiating HAART, who were hospitalized in the department of infectious diseases of our hospital from Jan. to Sept. 2012, were analyzed retrospectively. CD4+ T lymphocyte counts were compared between serum cryptococcal antigen positive patients and negative patients. Results Of 77 HIV/AIDS patients (53 males and 24 females), 48 (62.34%) were serum cryptococcal antigen positive, and 29 (37.66%) were serum cryptococcal antigen negative. The positive rate of serum cryptococcal antigen was 72.73% in the patients with CD4+ T lymphocyte count ≤50 /mm3. CD4+ T lymphocyte counts of the cryptococcal antigen positive patients were significantly lower than those of the negative patients (P=0.022). Conclusions This study reveals a high prevalence of cryptococcal antigen in HIV/AIDS patients without receiving HAART whose CD4+ T lymphocyte counts are lower. CD4+ T lymphocyte counts of HIV/AIDS patients with serum cryptococcal antigen positive are significantly lower than those of HIV/ AIDS patients with serum cryptococcal antigen negative (P<0.05).%目的 调查未接受高效抗反转录病毒治疗(highly active antiretroviral therapy,HAART)的HIV/AIDS患者血清隐球菌抗原的阳性率.方法 回顾性调查我院感染科2012年1-9月住院的77例未接受HAART的HIV/AIDS患者外周血CD4+T淋巴细胞计数及血清隐球菌抗原阳性率,比较隐球菌抗原阳性患者与阴性患者的CD4+T淋巴细胞计数.结果 77例(男53例,女24例)中,血清隐球菌抗原阳性48例,阳性率为62.34％,阴性29例,阴性率为37.66％.其中,CD4+T淋巴细胞计数≤50个/mm3的患者血清隐球菌抗原阳性率为72.73％.血清隐球菌抗原阳性患者外周血CD4+T淋巴细胞计数显著低于阴性患者(P=0.022).结论 未接受HAART的外周血CD4+T淋巴细胞计数较低的HIV/AIDS患者血清隐球菌抗原阳性率高,血清隐球菌抗原阳性患者CD4+T淋巴细胞水平低于阴性患者(P＜0.05).