进食对FibroScan检测乙型肝炎肝纤维化准确性的影响

摘要

Objective To investigate the effect of diets on the accuracy of FibroScan for the assessment of liver fibrosis in patients with chronic hepatitis B (CHB).Methods Fifty-seven CHB patients underwent both liver stiffness measurement (LSM) and liver biopsy.LSM was performed before meal and 2 hours after meal.With liver biopsy as the gold standard,the differences of LSM values before and after meal were compared and analyzed.Results The LSM values before and after meal were not significantly different (P=0.989).Pathological findings showed that the areas under the receiver operating characteristic curves (AUROCs) were 0.93,0.95 and 0.97 for patients with liver fibrosis stages 2-4,and the cut-off values were 8.1,11.0 and 17.3 kPa,respectively,before meal;the AUROCs were 0.93,0.96 and 0.95 for patients with liver fibrosis stages 2-4,and the cut-off values were 8.0,12.7 and 16.4 kPa,respectively,after meal.Conclusions LSM values are not significantly different before meal and 2 hours after meal in the morning.Diets have no effect on FibroScan for the assessment of liver fibrosis in CHB patients.%目的 探讨进食对FibroScan检测乙型肝炎肝纤维化的影响.方法 57例乙型肝炎肝纤维化患者分别于早晨空腹(餐前)和餐后2h(餐后)检测肝脏硬度值,同时行肝脏活体组织检查,以病理结果为“金标准”,分析餐前和餐后肝脏硬度值的差异.结果 餐前和餐后肝脏硬度值差异无统计学意义(P=0.989).病理检查的结果为:餐前FibroScan诊断S2、S3、S4期的受试者工作特征曲线下面积分别为0.93、0.95、0.97,诊断界值分别为8.1、11.0、17.3 kPa;餐后FibroScan诊断S2、S3、S4期的受试者工作特征曲线下面积分别为0.93、0.96、0.95,诊断界值分别为8.0、12.7、16.4 kPa.结论 早晨空腹和餐后2h肝脏硬度值无明显变化,进食对FibroScan检测乙型肝炎肝纤维化无影响.