肠道微生态与肝癌关系研究新进展

摘要

Due to the close anatomical and functional relationship between the liver and the intestine, intestinal microflora, interact with liver function through the liver-intestinal axis. It plays an important role in the development of the liver inflammation, fibrosis and tumor. Intestinal microflora disorders promote the progress of hepatocellular carcinoma (HCC), which is an international breakthrough in the pathogenesis of HCC in experimental animals. Key feature strains of the intestinal microflora may become new biomarkers and therapeutic targets of HCC. With the development of the second generation high throughput sequencing technology, the research of metagenomics has opened up a new way for us to understand the relationship between intestinal microflora and HCC from the great depth and breadth.%由于肝脏与肠道紧密的解剖与功能关系，肠道微生物通过肝-肠循环和微生态-肝脏轴与宿主相互作用，在肝脏炎症、慢性纤维化及肿瘤发生发展中发挥重要作用。肠道微生态失衡促进肝癌进展，这是国际上实验动物肝癌发病机制的突破性进展。肠道微生物中关键功能菌可能成为肝癌诊治的新型生物标志物和治疗靶点。随着第二代高通量测序技术的发展，元基因组学研究从极大的深度和广度为我们认识肠道菌群与肝癌的关系开辟了新的途径。