美罗培南合成用钯炭催化剂的制备及性能

摘要

改进了用于美罗培南合成中氢解脱苄用 Pd / C 催化剂的制备工艺，主要讨论载体粒度、预处理方式、活性组分溶液 pH、NaOH、NaHCO3和 Na2 CO3及用量和还原剂种类及用量对催化剂性能的影响。采用扫描电镜及透射电镜表征催化剂的微观形貌，结果表明，活性组分溶液 pH 对催化剂性能影响较大，（200~300）目的载体用0.15 mol·L -1的 NaOH 处理，用 Na2 CO3调节活性组分溶液至pH 为4，甲酸为还原剂，每克钯的甲酸用量为6 mL。制备钯质量分数为4.0%~4.6%的催化剂，与对比的5% Pd/ C 催化剂相比，具有更低的金属含量和相同的催化效率。利用 Na2 CO3调节活性组分溶液 pH，控制活性组分在载体表面的分布状态，得到不同活性及目标产物选择性的 Pd/ C 催化剂。%The preparation methods of palladium-carbon(Pd/ C)catalysts for the synthesis of meropenem was improved. The effects of particle size,pretreatment methods of AC( active carbon),pH values of active component solutions,NaOH,NaHCO3 and Na2 CO3 and their amounts and the kind and the dosage of the reducers on the performance of Pd / C catalysts were investigated. The mciro-morphology of Pd / C catalysts was characterized by SEM and TEM. The results showed that pH values of active component solutions had obvious influence on catalyst properties. Pd / C catalyst with the optimal performance was prepared under the condition as follows:active carbon with(200 - 300)mesh particle size pretreated by 0. 15 mol·L - 1 sodium hydroxide solution,pH = 4 of active component solution regulated by sodium carbonate,formic acid as the reducer,formic acid dosage 6 mL·(gPd)- 1 . Compared with the reference Pd / C catalyst with 5wt% Pd,the as-prepared Pd/ C catalyst with Pd mass fraction 4. 0% -4. 6% possessed the same catalytic efficiency and lower Pd content. Pd / C catalysts with different activity and selectivity to product were attained by using Na2CO3 to adjust pH values of active component solution and controlling active component distribution on the support surface.