替罗非班对老年急性冠脉综合征行PCI术患者近期预后的影响

摘要

Objective To study effects of short-term prognosis tirofiban on elderly acute coronary syndrome patients ( ACS) who un-derwentPCI.Methods 128casesofelderlypatientswithACSwhorecievedPCItreatmentinourhospitalwererandomlyobservationgroup and control group with 64 cases in each, control group given aspirin, chlorine which the gray oral therapy, observation group recieved tirofi-ban on the basis of control group.Results TIMI 3 flow rate of observation group was 98.44%, higher than 89.06%of the control group ( P<0.05);And the observation group, the incidence of stent thrombosis was 1.56%, lower than 10.94% in the control group ( P<0.05);The mild hemorrhage rate of observation group was 26.56%, significantly higher than that of control group 10.94%(P<0.05);The observation group and mortality of myocardial infarction, target vessel revascularization were significantly lower than the control group,it was statistically significant(P<0.05).Conclusion Tirofiban for treatment of elderly acute coronary syndrome patients (ACS) who underwent PCI, can effectively reduce the incidence of stent thrombosis and adverse cardiac events, is conducive to improve the prognosis in the near future.%目的：探讨替罗非班对老年急性冠脉综合征（ACS）行PCI（冠状动脉介入）术患者近期预后的影响。方法选择2011－10～2013－10间我院收治的行PCI术治疗的128例老年ACS患者，将其分为研究组和对照组。对照组给予阿司匹林、氯毗格雷口服治疗，研究组在此基础上给予替罗非班治疗。比较两组患者靶血管前向血流、支架内血栓、出血发生率及不良反应情况。结果研究组患者TIMI 3级血流率为98．44％，高于对照组的89．06％；支架内血栓发生率为1．56％，低于对照组的10．94％；轻微出血率为26．56％，显著高于对照组的10．94％，两组比较差异均有统计学意义（ P＜0．05）；研究组患者心肌梗死、靶血管血运重建及死亡率均显著低于对照组，差异有统计学意义（ P＜0．05）。结论对老年ACS患者行PCI术术中采用替罗非班治疗，能够有效地降低支架内血栓及不良心脏事件发生率，有利于改善患者的近期预后。