血清脂联素及CRP／APN比值的变化在腹部创伤患者病情监测中的意义

摘要

目的：探讨血清脂联素（ APN）及C反应蛋白（ CRP）与APN比值（ CRP／APN比值）的变化在腹部创伤患者病情监测中的意义。方法将本科室收治的80例腹部外伤患者依据AIS－ISS评分分为轻伤组及重伤组，将来本院体检的正常成年人30例作为对照组。分别于入院后即刻及第1 d、2 d、4 d、7 d共5个时间点，采用放射免疫法检测患者APN、CRP水平及CRP／APN比值，并同步进行全身炎症反应综合征（ SIRS）评分，对所得结果进行统计学分析及相关性分析。结果与对照组相比，轻伤组和重伤组患者的APN水平均明显降低（ P＜0.05），重伤组APN水平明显低于轻伤组（ P＜0.05）；血清CRP与CRP／APN比值与SIRS评分呈正相关，相关系数分别为0.81（P＜0.05）和0.91（P＜0.05），而APN水平与SIRS评分呈负相关（r＝－0.88，P＜0.05）。结论APN与CRP／APN比值可以作为评估腹部伤情严重程度的客观指标，有助于准确及时地评估病情。%Objective To investigate the clinical significance of serum adiponectin and ratio of CRP /APN in evaluating the illness state for abdominal trauma patients.Methods 80 patients were divided into mild trauma group and severe trauma group according to AIS -ISS score.And healthy adults who had physical examination in the hospital were regarded as the observation group .Concentration of adiponectin and CRP were detected when they were admitted to emergency room as well as 1nd,2th,4th and 7th day in the morning.Meanwhile, ration of CRP/APN and SIRS scoring were assessed .Statistic analysis and correlation analysis were performed .Rseults Compared with normal group ,the APN levels of mild trauma group and severe trauma group were lower ( P<0.05) ,while APN level of severe trauma group was significantly lower (P<0.05).Serum levels of CRP and CRP/APN ratio were positive correlated with SIRS score system ,and correlation coefficiency was0.81 (P<0.05) and 0.91 (P<0.05) respectively,while APN was negative correlated with SIRS score system (r=-0.88 ,P<0.05 ).Con clusion Concentration of APN and CRP/APN ratio could be objective index for evaluation of severity and prognosis in abdominal traumatic patients , and have a good predictive value on the severity of abdominal trauma.