Objective: To investigate relationship between the plasma N-Terminal brain natriuretie peptide (NT-proBNP) level and chronic heart failure (CHF) in chronic kidney disease (CKD) patients without dialysis. Method: The electrochemiluminescenee assay and the complete automatic biochemistry analyzer was respectively used to dectect NT-proBNP level and creatinine, urea nitrogen level in 59 cases chronic heart failure was significantly higher than that in patients with non-heart failure group [(5927.8±9628.value could be used to diagnose CHF with sensitivity of 93.2% (55/59) and specificity 90.0% (9/10) ;multiple regression analysis showed that LVEF and GFR are the independent factors to NT-proBNP level.Conclusion: There was significantly correlated ( r=-0.407, P<0.01) between NT-proBNP levels and heart function and kidney function in CKD patients without dialysis , NT-proBNP levels can be used to evaluate the CKD patients without dialysis as an indicators of cardiac function.%目的:探讨血浆N-末端脑利钠肽(NT-proBNP)与慢性肾脏病(CKD)非透析患者心功能不全的关系.方法:电化学发光法测定59例CKD非透析合并慢性心力衰竭(CHF)患者与正常对照组10例患者的血浆NT-proBNP水平,心脏超声测定心脏左室射血分数(LVEF),全自动生化仪检测血肌酐、尿素氮等.结果:①心表患者血浆NT-proBNP水平明显高于非心衰组患者[(5927.8±9628.6比80.3±46.4)ng/L,P<0.001];②如以120 ng/L为正常参考值,NT-proBNP诊断心衰的敏感性93.2%(55/59),特异性90.0%(9/10);③心衰患者NT-proBNP水平与LVEF呈负相关(r=-0.407,P<0.01),同时,心衰患者NT-proBNP水平与GFR也里负相关(r=-0.541,P<0.001);④多元回归分析显示LVEF和GFR均是影响NT-proBNP水平的独立因素.结论:CKD非透析患者NT-proBNP水平与心功能、肾功能相关,NT-proBNP水平可作为一项评价CKD非透析患者心功能的指标.
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