阿托伐他汀钙在急性脑梗塞患者中的应用研究

摘要

目的:探讨阿托伐他汀钙对急性脑梗死患者血清C-反应蛋白、白细胞介素-6和白细胞介素-10的影响,以及临床治疗效果.方法:80例急性脑梗死患者随机分成观察组和对照组各40例,对照组采用常规治疗,观察组在常规治疗的基础上加用阿托伐他汀钙;分别在治疗前及治疗1d、3d、7d、14d测定患者血清CRP、IL-6、IL-10的浓度,两个月后评价临床治疗效果.结果:观察组在CRP、IL-6、IL-10的水平改变明显优于对照组,临床总有效率高于对照组,差异均存在统计学意义(P＜0.05).结论:阿托伐他汀钙可明显降低急性脑梗死患者血清CRP、IL-6,升高IL-10水平,具有减轻炎症反应的神经保护作用,临床有效率高.%To explore the effect of atovastatin calcium on C-reactive protein(CRP) 、interleukin-6 (IL-6) 、interleukin-10 (IL-10) and clinical treatment effect. Method:80 cases patients with acute cerebral infarction were randomly divided into the intervention group (40 cases) and control group (40 cases ). The control group were treated with routine treatment,the intervention group were treated with atovastatin calcium. Serum levels of CRP、IL-6、IL-10 were measured before treatment and after treatment of ld、3d、7d、14d,and the clinical treatment effect was evaluated after two months. Result:After treatment，The CRP、IL-6 and IL-10 levels of change in intervention group were better than that in control group,the total effective rate was higher than that incontrol group, there were significant differences ( P＜0.05 ). Conclusion:Atovastatin calcium in patients with acute cerebral infarction could prevent the increase in serum CRP、IL-6 level， increase the level of IL-10, have anti-inflammatory effects, and improve clinical treatment effect.