Design of biodegradable nanoparticles of atorvastatin calcium (nanostatin) for oral delivery and their evaluation in high fat diet fed rats for improved efficacy with reduced toxicity

摘要

Atorvastatin calcium (AC) is the world's best selling drug, however, is associated with serious adverse effects with chronic administration. The long half life and accumulation of the drug during chronic administration results in adverse effects like Rhabdomyolysis. We successfully attempted the oral nanoparticulate approach resulting in no adverse effects without the loss of activity.