纤维蛋白原与支架内再狭窄的相关性研究

摘要

目的：探讨纤维蛋白原（ FIB）与支架内再狭窄的相关性。方法：选取我院收治的冠心病行经皮冠状动脉介入术（ PCI）治疗的患者64例，本组患者均于术后3～12个月内完成冠状动脉造影术（ CAG）复查，根据有无支架内狭窄分为再狭窄组和无再狭窄组，术前检测血清FIB、低密度脂蛋白酯（LDL－C）、高密度脂蛋白酯（HDL－C）、总胆固醇（TC）、甘油三酯（TG）、载脂蛋白B（ApoB）、载脂蛋白A1（ ApoA1），比较FIB在两组间有无差异，并且对FIB 与再狭窄进行偏相关分析及多元逐步回归分析。结果：FIB在术后支架内再狭窄组明显高于无狭窄组（ P＜0．001）；多元线性回归分析发现，FIB与再狭窄的相关性是除TC外的第二个最强指标（ P＜0．001）。结论：FIB水平异常升高与PCI术后支架内再狭窄关系密切相关。%Objective:To explore the correlation of fibrinogen ( FIB ) and in-stent restenosis ( ISR ) . Method:A total of 64 patients suffered from coronary disease, underwent percutaneous coronary intervention (PCI), and were rechecked through coronary angiography (CAG) within 3 to 12 months after operation, They were divided into the restenosis group and the non-restenosis group according to if there was an in-stent restenosis or not.The serum FIB, TC, TG, LDL-C, HDL-C, and ApoB, ApoAl were detected before operation.The comparison of FIB between two groups was compared.Partial correlation analysis and multiple regression analysis were done on FIB and restenosis.Result:The FIB level in the restenosis group was signif-icantly higher than that in the non-restenosis group ( P<0.001) .The multiple regression analysis showed that the correlation of FIB and restenosis was the second most strong indicator except TC ( P<0.001 ) .Conclu-sion:The abnormal elevation of FIB level is closely correlated with in-stent restenosis after PCI.The control-ling of FIB level may probably become the effective method to reduce the occurrence rate of in-stent resteno-sis after PCI.