复方丹参滴丸联合厄贝沙坦对老年早期2型糖尿病肾病患者尿微量白蛋白影响的研究

摘要

目的：探讨复方丹参滴丸联合厄贝沙坦对老年早期2型糖尿病肾病患者尿微量白蛋白的影响。方法：选择肾内科诊治的60例老年早期2型糖尿病肾病患者纳入本研究，将其分为观察组和对照组，各30例。对照组服用厄贝沙坦，而观察组服用复方丹参滴丸联合厄贝沙坦，对两组患者治疗前后血液流变学的变化、生化指标及UAER的变化进行分析。结果：对照组患者治疗前，TC、TG、Scr、BUN及UAER为6．5±0．5、2．5±0．4、80±10μmoL／L、5．7±1．7mmoL／L及111．4±191．2μg／min，治疗后，各指标为6．5±0．4、2．4±0．3、78±9μmoL／L、5．6±1．3mmoL／L及73．2±9．1μg／min，对各指标及血液流变学对比分析后，差异无统计学意义（P＞0．05）；而观察组患者在治疗前后各指标分别为6．5±0．6、2．6±0．4、78±11μmoL／L、6．0±1．5mmoL／L及112．8±0．3μg／min和4．8±0．6、1．5±0．2、75±12μmoL／L、5．7±1．4mmoL／L及60．1±9．5μg／min，均有所降低，对各指标及血液流变学对比分析后，差异有统计学意义（P＜0．05）。结论：厄贝沙坦联合复方丹参滴丸对于老年早期2型糖尿病肾病患者具有显著的疗效。%Objective: To investigate the impact of compound Danshen dripping pills combined with irbesartan for elderly type 2 diabetic nephropathy early microalbuminuria .Method:60 patients with elderly type 2 diabetic nephropathy early microalbuminuria were chosen in our hospital to receive treatment , divided into two groups, with 30 patients in each group respectively .Patients in the control group were treated with irbesartan, and patients in the observation group were treated with compound Danshen dripping pills com-bined with irbesartan .Before and after treatment , the change in blood rheology , and biochemical parameters and changes in UAER two groups of patients were analyzed .Result: The control group of patients before treatment, TC, TG, Scr, BUN and UAER was 6.5 ±0.5,2.5 ±0.4,80 ±10μmoL /L, 5.7 ±1.7 mmoL /L and 111.4 ±191.2μg/min, after treatment, all indicators 6.5 ±0.4,2.4 ±0.3,78 ±9μmoL /L, 5.6 ±1. 3 mmoL /L and 73.2 ±9.1μg/min, after each index and blood rheology comparative analysis , the differ-ence was not statistically significant ( P>0.05) ;while observing patients before and after treatment of each index were 6.5 ±0.6,2.6 ±0.4,78 ±11μmoL /L, 6.0 ±1.5mmoL /L and 112.8 ±0.3μg/min and 4.8 ± 0.6,1.5 ±0.2,75 ±12μmoL /L, 5.7 ±1.4mmoL /L and 60.1 ±9.5μg/min, were decreased after each index and blood rheology comparative analysis , the difference was statistically significant (P <0.05).Con-clusion:Irbesartan joint compound Danshen dripping pills for early type 2 diabetic nephropathy in elderly patients have a significant effect .