血小板活化因子监测对新生儿缺氧缺血性脑病治疗效果评价的临床意义

摘要

目的：探讨新生儿缺氧缺血性脑病治疗过程中血小板活化因子监测对疗效监测的临床价值。方法：对60例HIE患儿采用单唾液酸四己糖神经节苷脂联合复方丹参注射液治疗，于治疗前、治疗第3、7、10、14、21、28天分别进行NBNA评分及PAF检测，根据治疗第28天NBNA评分将患儿分为有效组与无效组，对比两组之间不同治疗时期PAF检测结果，并分析不同治疗时期PAF检测结果与NBNA评分的相关性。结果：治疗前及治疗第3天两组患儿PAF 检测结果无统计学差异（ P＞0．05），自治疗第3天起至疗程结束日，有效组PAF均显著低于无效组（ P＜0．01）；PAF 浓度与NBNA评分呈现出显著负相关（ P＜0．05）。结论：PAF在HIE患儿预后的评估以及治疗效果的评价等方面均具有重要临床价值，操作简便，客观准确，灵敏度高，值得推广。%Objective:To discuss the clinical significance of platelet activating factor ( PAF) monitoring in treatment evaluation in newborn with HIE .Method:60 newborn with HIE were treated with ganglioside GMI combined with danshen injection , the NBNA score were evaluated and the PAF detection were per-formed before and 3, 7, 10, 14, 21, 28 days after the treatment , the newborn were divided into the effective group and the ineffective group according to the NBNA score 28 days after the treatment , and the PAF in dif-ferent treatment period were contrasted between the two groups , the correlation between PAF and NBNA score in different treatment periods were analyzed .Result:There's no significantly difference between the two groups in PAF before and 3 days after the treatment ( P>0.05);but PAF in the effective group were signifi-cantly lower than the ineffective group 7, 10, 14, 21, 28 days after the treatment ( P<0.01);there's a sig-nificantly negatively correlation between PAF and NBNA score (P<0.05).Conclusion: PAF has important significance in the assessment of prognosis and evaluation of treatment effect in newborn with HIE , and it’ s simple, objective and accurate, high sensitivity, worthy of promotion.