磷酸甘油酸变位酶-1在不同分型前列腺炎患者睾丸组织中的表达及临床意义

摘要

Objective:To observe the phosphoglycerate mutase (PGAM1)-1 expression in testicular tissue of patients with different types of prostatitis, to analyze the clinical significance of detecting PGAM1 expression.Methods: Type I,II,III and IV prostatitis patients and healthy population of the testicular tissue specimens were collected.The level of PGAM1 expression was detected by immunohistochemical.The difference of PGAM1 expression in patients with different types of prostatitis was analyzed.The relationship between the expression of PGAM1 and the levels of follicle stimulating hormone, luteinizing hormone and testosterone was analyzed.Results: There was no significant difference in the expression of PGAM1 in the testis tissue of patients with typeⅠ(P>0.05).The expression of PGAM1 in testis tissues of patients with type II, III and IV prostatitis was significantly different from that in healthy people (P<0.05).There was no significant difference in the levels of follicle stimulating hormone, luteinizing hormone (LH) and T hormone (P>0.05) in patients with type Ⅰ prostatitis (PGAM1).However, there were significant differences in the levels of follicle stimulating hormone, luteinizing hormone and testosterone in patients with type PGAM1, type III and type IV prostatitis (P<0.05).Conclusion: In addition to the patients with type Ⅰ prostatitis, the expression of PGAM1 of patients with type II, III and IV prostatitis was lower.The abnormal expression of PGAM1 had an effect on spermatogenesis in patients with testicular tissue.Therefore, the detection of PGAM1 has a certain clinical value in the diagnosis of patients with prostatitis.%目的:观察磷酸甘油酸变位酶-1(PGAM1)在不同分型前列腺炎患者睾丸组织中的表达差异,并分析PGAM1表达检测的临床意义.方法:收集Ⅰ型、Ⅱ型、Ⅲ型、Ⅳ型前列腺炎患者和健康体检人群的睾丸组织标本,采用免疫组化检测PGAM1表达水平,分析不同分型前列腺炎患者PGAM1表达差异,并分析PGAM1表达与生精功能指标卵泡刺激素、黄体生成素、睾酮水平的关系.结果:Ⅰ型前列腺炎患者睾丸组织标本PGAM1表达与健康体检人群比较无显著差异性(P>0.05),Ⅱ型、Ⅲ型、Ⅳ型前列腺炎患者睾丸组织标本PGAM1表达与健康体检人群比较有显著差异性(P<0.05);Ⅰ型前列腺炎患者中PGAM1低表达者的卵泡刺激素、黄体生成素、T激素水平与健康体检人群比较无显著差异性(P>0.05),但Ⅱ型、Ⅲ型、Ⅳ型前列腺炎患者中PGAM1低表达者的卵泡刺激素、黄体生成素、睾酮水平与健康体检人群比较有显著差异性(P<0.05).结论:除Ⅰ型前列腺炎患者外,Ⅱ型、Ⅲ型、Ⅳ型前列腺炎患者PGAM1呈异常的低表达,而PGAM1呈异常的低表达对患者睾丸组织生精功能产生影响,因此PGAM1检测在前列腺炎患者病情及生精功能障碍诊断中具有一定的临床价值.