糖尿病肾病患者微炎症状态与营养不良的相关性研究

摘要

目的:探讨糖尿病肾病患者微炎症状态与营养状况的关系.方法:测定120例不同分期的糖尿病肾病患者治疗前的空腹血糖(GLU)、血清白蛋白(ALB)、前白蛋白(preALB)、肌酐(CREA)、血尿素氮(BUN)、总胆固醇(CHOL)、C反应蛋白(CRP)、超敏C反应蛋白(Hs-CRP)、白介素-6(IL-6)、尿蛋白量(24hUpro)、肿瘤坏死因子α(TNF-α)等指标,分析微炎症状态指标与营养状况指标之间的相关关系.结果:不同分期糖尿病肾病患者的微炎症状态指标与营养状况指标存在显著统计学差异(p<0.05),随着病情加重,微炎症状态及营养不良状况更加严重.相关性分析显示:C反应蛋白(CRP)与血清白蛋白(ALB)、前白蛋白(preALB)水平呈明显负相关关系(p<0.05),与白介素-6(IL-6)、肿瘤坏死因子α(TNF-α)呈正相关关系(p<0.05);血清白蛋白(ALB)与前白蛋白(preALB)、肌酐水平(CREA)、年龄呈正相关关系(p<0.05).结论:糖尿病肾病患者中微炎症状态与营养不良存在相关关系,微炎症状态会加重营养不良,同时又受营养不良的影响,临床上应引起重视.%Objective:To discuss the relationship between micro-inflammatory state and malnutrition in patients with diabetic nephropathy.Methods:120 patients of different stages of diabetic nephropathy were ob-served,we measured the level of nutrition and micro-inflammatory markers such as GLU,ALB,CREA,BUN, CRP ,IL-6,TNF-αbefore treatment to analyse the relationship between micro-inflammatory status and nutri-tion status.Results:Nutrition and micro-inflammatory status were different in different stages of diabetic ne-phropathy(p<0.05),the level of nutrition and inflammatory markers were gradually increased along with the progress of DN. There was negative correlation between CRP and ALB, preALB, positive correlation between CRP and IL-6,TNF-α( p<0.05);Also positive correlation was found between ALB and preALB,CREA,age (p<0.05).Conclusions:The micro-inflammatory status was correlated with malnutrition,micro-inflammatory can aggravate malnutrition,and micro-inflammatory can be influenced by malnutrition,clinic attention should be paid.