目的:探讨与对比乌拉地尔与硝普钠对高血压脑出血早期活动性出血的效果.方法:收集2015年1月至2017年6月入院的120例高血压脑出血患者随机分为两组,乌拉地尔患者给予乌拉地尔治疗,硝普钠组患者则给予硝普钠,比较两组患者血肿量、神经功能评分、疾病相关参数、远期预后与不良反应.结果:乌拉地尔组患者治疗后1周、2周与四周血肿量均显著性低于硝普钠组,CSS 评分均显著性高于硝普钠组;治疗后收缩压、全血高切还原粘度、全血低切还原粘度、血浆粘度、红细胞沉降率与红细胞比积组间比较均显著性低于硝普钠组;治疗后3个月MMSE评分与FMA评分组间比较均显著性高于硝普钠组,差异有统计学意义(P<0.05);两组患者治疗期间药物不良反应率比较差异无统计学意义(P>0.05).结论:相比较硝普钠,乌拉地尔对高血压脑出血早期活动性出血的疗效更为显著,具有借鉴意义.%Objective:To investigate and compare the effect of urapidil and sodium nitroprusside on ear-ly active bleeding after hypertensive intracerebral hemorrhage. Methods: 120 patients with hypertensive in-tracerebral hemorrhage admitted from January 2015 to June 2017 were randomly divided into two groups:ura-pidil and uracil sodium,sodium nitroprusside and sodium nitroprusside respectively Group hematoma volume, neurological score,disease-related parameters,long-term prognosis and adverse reactions. Results:The he-matoma volume of the patients in the urapidil group was significantly lower than those in the sodium nitroprus-side group at 1 week, 2 weeks and 4 weeks after treatment, and CSS scores were significantly higher than those in the sodium nitroprusside group. After treatment,the systolic blood pressure Viscosity,low cut-off vis-cosity,plasma viscosity, erythrocyte sedimentation rate and hematocrit were significantly lower than those in sodium nitroprusside group. MMSE score and FMA score were significantly higher than those in the three months after treatment There was a significant difference between sodium nitroprusside group and sodium nitro-prusside group (P <0.05). There was no significant difference in ADR between the two groups during treat-ment (P> 0.05). Conclusion:Compared with sodium nitroprusside,urapidil has a more significant effect on early active bleeding in patients with hypertensive intracerebral hemorrhage.
展开▼
