活血化瘀方对乳腺增生病患者血管内皮生长因子及碱性成纤维细胞生长因子的影响

摘要

Objective To investigate the effect and clinical efficacy of blood - activating and stasis - dissolving prescription on vascular endothelial growth factor and basic fibroblast growth factors of patients with cyclomastop-athy. Methods 88 patients with cyclomastopathy were randomly divided into two groups. Treatment group received blood - activating and stasis - dissolving prescription. Control group received conventional western therapy. 30 health cases were as normal control group. The changes of VEGF and bFGF in serum in three groups were measured by ELISA. Results The total effective rate in treatment group was 91. 67% and 89. 29% in control group. There was no difference between two groups on the total effective rate ( P >0.05). VEGF and bFGF before treatment in control group and treatment group were higher than those in normal control group ( P < 0. 05 ). VEGF and bFGF after treatment were decreased as compared with those before treatment in two groups ( P < 0. 05). There was no difference between two groups on VEGF and bFGF after treatment ( P >0.05). VEGF levels in two groups after treatment were pretty as those of normal control group ( P >0.05). Conclusion The over - expression of VEGF and bFGF in cyclomastopathy suggested that angiogenesis is an important part of the development of cyclomastopathy. Blood - activatingand stasis - dissolving prescription can reduce the contents of VEGF and bFGF in serum of patients, can block angiogenesis , promote lesion dissipation, absorption, and is an effective prescription for the treatment of cyclomastopathy.%目的 观察活血化瘀方对乳腺增生病患者血管内皮生长因子(VEGF)及碱性成纤维细胞生长因子(bFGF)的影响和临床疗效.方法 将88例乳腺增生病患者随机分为2组,治疗组60例予活血化瘀方,对照组28例子西医常规治疗.2组均治疗3个疗程,随访3个月.并选择同期健康者30例为正常对照组.采用酶联免疫法测定3组治疗前后血清VEGF及bFGF变化,统计临床疗效.结果 治疗组总有效率91.67％,对照组总有效率89.29％,2组总有效率比较差异无统计学意义(P＞0.05),疗效相当.2组治疗前VEGF及bFGF含量均高于正常对照组(P＜0.05).2组治疗后VEGF及bFGF含量均较本组治疗前明显降低(P＜0.05),而组间比较差异无统计学意义(P＞0.05).2组治疗后VEGF含量与正常对照组相当(P＞0.05),bFGF仍高于正常对照组(P＞0.05).结论 VEGF、bFGF在乳腺增生病中过度表达,提示血管生成是其发生发展的重要环节,活血化瘀方可降低患者血清中VEGF、bFGF含量,阻断血管生成,促使病灶消散、吸收,为治疗乳腺增生病的有效方药.