ERK1/2研究进展及其与神经胶质瘤相关性

摘要

细胞外信号调节激酶(Extracellular signal-regulated kinase,ERK)是有丝分裂原活化蛋白激酶(Mitogen-activated protein kinases,MAPKs)家族的一个重要亚族.ERK的功能是控制细胞分化,ERK的活化被认为与细胞的增殖、分化、迁移、侵袭、凋亡、癌性转化等密切相关.研究并利用ERK1/2在神经胶质瘤形成中的作用能更好的指导神经胶质瘤治疗策略的制定,本文就近年来ERK1/2研究进展及与神经胶质瘤相关性予以综述.%The extracellular signal-regulated kinase (ERK) is an important subtribe of the family of mitogen-acti-vated protein kinases (MAPKs). The function of ERK is regulating cell differentiation. The activation of ERK is considered to be closely related with cell proliferation, differentiation, migration, invasion, apoptosis and malignant transformation. Studying and understanding the role of ERK1/2 in the formation of glioma provides guidance and strategies for the treatment of glioma. This review presents the progress of ERK1/2 and illustrates its relationship with gliomain.