目的 了解顺铂联合苦参碱胸腔内化疗治疗恶性胸腔积液对患者血清癌胚抗原和免疫功能的影响.方法 选择60例恶性胸腔积液患者,随机分为治疗A、B组和对照组.采用中心静脉导管胸腔闭式引流后,将顺铂和苦参碱联合注入胸腔,治疗A组:苦参碱注射液150 mg+顺铂40 mg十Ns 40 ml;治疗B组:苦参碱注射液150 mg+顺铂60 mg+NS 40ml;对照组:顺铂60mg+NS 40ml.结果 治疗A组和治疗B组CEA明显降低(P<0.05),外周血中T细胞亚群(CD<,3>、CD<,4>、CD<,8>、CD<,4>/CD<,8>)和血清免疫球蛋白(IgG、IgA、IgM)明显升高(P<0.05).治疗后治疗组CEA比对照组明显降低(P<0.05),外周血中T细胞亚群和血清免疫球蛋白明显升高(P<0.05).结论 苦参碱联合顺铂胸腔内化疗治疗恶性胸腔积液,能改善患者免疫功能,增加疗效.%Objective To comprehend the effect of cis-platinum (DDP) combined with matrinc on CEA and immune function in malignant pleural effusion. Methods 60 cases with malignant pleural effussion were divided into three groups. The treated groups were infused by different doses of DDP and matrine into the thoracic cavity with malignant pleural effussion after closed thoracic drainage with central venous catheters. The control group were infused by DDP after the same treatment. Results After the treatment, the contents of CEA in the treated groups and the control were depressed obviously (P＜0.05), and the T cell subset (CD3, CD4, CD8, CD4/CD8) and the contents of serum immune globulin in the periphery blood were significantly improved (P＜0.05). The contents of CEA in the treated groups were depressed obviously than that in the control group (P＜0.05), and the contents of serum immune globulin in the periphery blood were significantly improved than that in the control group (P＜0.05). Conclusion Cis-platinum (DDP) combined with matrine can improve the immune function and increase the curative effect in patients with malignant pleural effussion.
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