神经肽Y和神经降压素与高血压病的研究进展

摘要

Neuropeptide Y (NPY) is a containing 36 amino acid residues peptides, extremely rich in human and other mammalian circulatory system. Neurotensin (NT) is a purification of bioactive peptide, widely distributed in the human heart and vascular. Recent numerous studies showed that NPY and NT took part in the regulation of cardiovascular function and the pathophysiology of cardiovascular disease by a variety of mechanisms, and closely related to with the development of hypertension. This article reviews the advancement in relationship between NPY, NT and Hypertension.%神经肽Y(NPY)是一种含有36个氨基酸残基的多肽,人体和其他哺乳动物的循环系统中含量极其丰富;神经降压素(NT)是分离纯化的一种生物活性多肽,广泛分布于人体的心脏和血管.近年大量研究提示NPY、NT可通过多种机制参与心血管功能的调节及心血管疾病的病理生理过程,且与高血压病的发生发展密切相关,本文将就此展开相关综述.