摘要：
Objective To investigate the effect of breast conserving surgery on neurotensin (NTS) and its receptor 1(NTR1) in patients with breast cancer.Methods From May 2012 to May 2015,200 patients with breast cancer,aged 44.7 years(range,32-56 years),were treated at Tiantan Hospital,Capital Medical University.All patients were divided into control group (n =100) and observation group (n =100).The patients in the control group were treated with radical operation and the patients in the observation group were treated with breastconserving surgery.The positive rate of NTS and NTR1 before and 1 week after operation,WHOQOL-100 (It includes four aspects:physiological state,psychological state,environmental condition and social function) 1 d before surgery,3 months and 6 months after surgery,and the incidence of postoperative complications 1 week after surgery were compared between the two groups.Measurement data with normal distribution were described as mean± standard deviation (Mean ± SD) and analyzed by the t test.Count data were analyzed by chi-square test.Results The positive rate of NTS (17.00％) in the observation group was significantly lower than that in the control group (36.00％) (t =9.267,P =0.002),The positive rate of NTR1 (19.00％) was significantly lower than that in the control group (33.00％) (t =5.094,P =0.024).The physiological status,psychological state,environmental condition and social function of 3 months after surgery of the observation group were (62.57 ± 5.73),(63.48 ±5.91),(68.73 ±6.32),(64.06 ±5.94) scores,respectively,and the control group were (53.47 ±5.38),(55.62 ±5.54),(60.38 ±6.14),(55.86 ±5.66) scores,respectively,showing statistically significant differences between the two groups (P ＜ 0.05).The physiological status,psychological state,environmental condition and social function of 6 months after surgery were (73.74 ±t 6.19),(76.27 ± 6.32),(78.85 ±6.77),(73.53 ±6.58) scores in the observation group,and (64.18 ±5.67),(67.38 ±6.02),(69.64 ± 6.43),(63.28 ± 6.17) scores in the control group,showing statistically significant differences between the two groups (P ＜ 0.05).The incidence of postoperative complications in the observation group (6.00％) was significantly lower than that in the control group (18.00％) (P ＜ 0.05).Conclusion Breast conserving surgery can reduce the expression level of NTS and NTR1 in breast cancer patients,It is related to reducing the incidence of postoperative complications and improving the quality of life of patients.%目的 探讨保乳手术对乳腺癌患者神经降压素(NTS)及其受体1(NTR1)的影响.方法 回顾性分析2012年5月-2015年5月首都医科大学附属北京天坛医院收治的200例乳腺癌患者,平均年龄44.7岁,年龄范围32 ～ 56岁,均为女性.按照手术方式不同将所有患者分为对照组(n=100)和观察组(n=100).对照组患者予以根治性手术治疗,观察组患者予以保乳手术治疗.比较术前及术后1周两组患者NTS及NTR1阳性率,术前1 d和术后3个月、6个月的世界卫生组织生存质量测定量表(WHOQOL-100)评分(包括4个方面:生理状态、心理状态、环境状况及社会功能)及术后1周并发症发生率.正态分布的计量资料以均数±标准差(Mean±SD),组间比较采用t检验;计数资料组间比较采用x2检验.结果 术后观察组的NTS阳性率(17.00％)显著低于对照组(36.00％),差异具有统计学意义(t=9.267,P=0.002),NTR1阳性率(19.00％)显著低于对照组(33.00％),差异具有统计学意义(t=5.094,P=0.024).术后3个月观察组的生理状态、心理状态、环境状况和社会功能评分分别为(62.57±5.73)、(63.48±5.91)、(68.73±6.32)、(64.06±5.94)分,对照组分别为(53.47±5.38)、(55.62±5.54)、(60.38 ±6.14)、(55.86 ±5.66)分,两组相比差异具有统计学意义(P＜0.05).术后6个月观察组的生理状态、心理状态、环境状况和社会功能评分分别为(73.74±6.19)、(76.27 ±6.32)、(78.85±6.77)、(73.53±6.58)分,对照组的分别为(64.18 ±5.67)、(67.38±6.02)、(69.64±6.43)、(63.28 ±6.17)分,两组相比差异具有统计学意义(P＜0.05);观察组的术后并发症发生率(6.00％)显著低于对照组(18.00％),差异具有统计学意义(P＜0.05).结论 保乳手术能够降低乳腺癌患者神经降压素及其受体1术后表达水平,与降低患者术后并发症发生率及提高患者生活质量有关.
