宫腔内供精人工授精结局影响因素分析

摘要

Objective To analyze the parameters affecting the pregnancy rate in intrauterine artificial insemination with donor's sperm (AID-IUI). Methods A total of 345 AID-IUI cycles in our center were selected. Chi-square test and multiple unconditional logistic regression were performed. Results The pregnancy rate of 345 AID-IUI cycles were 24.1%. The pregnancy outcome showed no statistically significant difference between the groups of different age and duration of infertility (P>0.05). Multivariable stepwise logistic regression model revealed that the number of AID-IUI cycles was a risk factor that affected the pregnancy rate of per cycle. The OR value for 2 cycles group and 3 cycles group were 6.78 [95%CI(2.75~16.71)] and 2.87[95% CI(1.12~7.36)], respectively. Conclusion The number of AID-IUI cycles was one of the most important factors affecting the pregnancy rate of per cycle.%目的 探讨多种因素对宫腔内供精人工授精(AID-IUI)治疗结局的影响.方法 回顾性分析在本中心实施的345个AID-IUI治疗周期,对AID-IUI成功率与女方年龄、治疗周期数等因素的关系进行x2检验及非条件逐步Logistic回归分析.结果 345个AID-IUI周期,周期临床妊娠率为24.1％.x2检验显示年龄、不孕年限等因素对AID-IUI结局的影响无统计学意义(P＞0.05); Logistic回归分析显示助孕周期次数是影响AID-IUI周期临床妊娠率的危险因素(P＜0.01),2次组和≥3次组的OR值分别为6.78 [95％CI (2.75～16.71)]及2.87[95％CI(1.12～7.36)].结论 助孕周期次数是影响AID-IUI周期临床妊娠率的重要因素.