Objective To discuss the clinical effects of Rabeprazole combined with Hydrotalcite in the treatment of refractory gastroesophageal reflux disease (GERD). Methods 120 patients with GERD were randomly divided into two groups. The control group (60 cases) were given hydrotalcite only, while the observation group (60 cases) were given Rabeprazole combined with Hydrotalcite. Then the improvements of clinical symptoms and gastric muco-sa repair under electronic gastroscope were compared between the two groups. Results In the improvements of clinical symptom and gastric mucosa repair under electronic gastroscope, the total effective rate of the observation group (95.0%) was significantly higher than that of the control group (78.3%), P<0.01. Conclusion Rabeprazole combined with Hydrotalcite is effective for treating patients with GERD. The curative effect is reliable, persistent, and safe, with fewer side effects, which could be widely applied.%目的 探讨肿瘤坏死因子拮抗剂(依那西普)对风湿病的临床疗效.方法 将我院收治的类风湿性关节炎患者52例随机分为实验组(27例)以及对照组(25例),实验组采用依那西普进行治疗,对照组采用硫酸羟氯喹片治疗,对患者进行为期6个月的随访.结果 实验组患者临床有效率为92.59％,显著高于对照组的76.00％；实验组患者在治疗后关节疼痛数、关节压痛积分、晨僵、20 m步行时间、关节肿胀积分等临床指标比较中均优于对照组(P＜0.05)；实验组患者在治疗后其风湿因子、C反应蛋白、血沉治疗后指标较对照组差异均有统计学意义(P＜0.05).结论 对风湿病患者采用肿瘤坏死因子拮抗剂进行治疗,可有效改善患者预后,提高患者治疗后生活质量.
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