Antagonists of tumor necrosis factor 1, a binder, a monu00c8mero antibody domu00ecnio (DAB), nucleic acid, vector, host cell, methods for producing a polipeptu00ecdeo, a monu00c8mero of DAB, a binder multiespecu00ecfico, and a format of the antibody, and to treat or prevent, suppress a doe Difference between, the composition, the use of an antagonist, the format of antibody, polipeptu00ecdeo, and.The antibody or fragment of connection of antu00ecgeno)

摘要

Antagonists of tumor necrosis factor 1, a binder, a monu00c8mero antibody domu00ecnio (DAB), nucleic acid, vector, host cell, methods for producing a polipeptu00ecdeo, a monu00c8mero of DAB, a binder multtespecu00ecfico, and a format of the antibody, and to treat or prevent, suppress a doe Difference between, the composition, the use of an antagonist, the format of antibody, polipeptu00ecdeo, and.The antibody or fragment of antu00ecgeno connection of the same. The invention provides methods to treat inflammatory diseases (e.g., chronic inflammatory diseases, comprising administering an antagonist) receptor of the tumor necrosis factor 1.The invention also provides ligands that contain an immunoglobulin variable domain monomer (single domain antibody, DAB) that binds to tumor necrosis factor receptor 1, and methods of using the ligands. Are also provided nucleic acids encoding the ligands, recombinant host cells and methods for preparing the binders.