Objective To investigate the risk factors of the prognosis of metaphase and advanced nasopha-ryngeal carcinoma with emphasize radiotherapy and homeochronous chemotherapy. Methods The clinical data of 100 patients with metaphase and advanced nasopharyngeal carcinoma who received radiotherapy combined with homeochronous chemotherapy from Jan. 2006 to Dec. 2006 were analyzed. General information, clinical data, and imaging date were classified as the investigative factor. COX model of survival were established, and the related factors and risk factors for survival were analyzed. Results Univariate analysis showed that stage of tumor, number of infiltrated organ, disciplinary radiotherapy or not, regular chemotherapy or not, and pristine relapse were the related factors of the prognosis. Cox & apos showed that number of infiltrated organ, disciplinary radiotherapy or not, regular chemotherapy or not, and pristine relapse were the independent risk factors for prognosis. Conclusion The prognosis of metaphase and advanced nasopharyngeal carcinoma with radiotherapy combined homeochronous chemotherapy was corelated to tumor progression and the implement of radiotherapy combined chemotherapy. Early diagnosis and regular treatment should were reinforced.%目的 探讨中晚期鼻咽癌常规分次放疗联合同步化疗患者预后的风险因素.方法 选择我院2006年01～12月常规分次放疗联合化疗的中晚期鼻咽癌患者临床资料100例,将患者一般资料、临床资料及影像学资料列为研究因素,建立COX生存风险比例模型,分析影响患者生存的相关因素及风险因素.结果 单因素筛选结果显示:肿瘤分期、侵犯器官数目、规律放疗与否、规律化疗与否、早期复发是影响预后的相关因素.COX分析结果显示:规律放疗与否、规律化疗与否、早期复发及肿瘤侵犯器官数目是常规分次放疗联合同步化疗中晚期鼻咽癌患生存风险因素.结论 中晚期鼻咽癌常规分次放疗联合同步化疗患者的预后与肿瘤的进展及放化疗的实施情况相关,应加强早期诊断及规律治疗.
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