补锌疗法佐治婴幼儿轮状病毒肠炎的临床效果观察

摘要

目的 观察补锌疗法对轮状病毒肠炎治疗的效果.方法 将2010年8月至2012年10月间收治的140例轮状病毒肠炎患儿随机分为观察组(n=76)与对照组(n=64),对照组患儿给予病毒唑、蒙脱石散、西咪替丁及补液纠酸等综合疗法,观察组在此基础上加服葡萄糖酸锌片或甘草锌颗粒,治疗72 h后观察两组临床疗效,治疗14 d后对比两组血锌含量与免疫球蛋白水平.结果 ①治疗后2周,患儿血锌与IgG、IgA、IgM含量均有所上升,观察组血锌、IgG、IgA水平明显高于对照组(P＜0.05).②治疗后观察组腹泻持续天数为(6.21±1.52)d,明显少于对照组的(7.14±1.82)d (P＜0.05).③治疗72h后,两组患儿临床疗效构成不同,观察组总体有效率与显效率均高于对照组(P＜0.05).结论 婴幼儿轮状病毒肠炎在常规基础上佐以补锌疗法能提高患儿免疫功能,缩短病程,提高治疗有效率.%Objective To observe the clinical efficacy of zinc in the treatment of infantile rotavirus enteritis.Methods One hundred and forty patients admitted from Aug.2010 to Oct.2012 were randomly divided into the treatment group (n=76) and the control group (n=64).The control group was given ribavirin+cimetidine+smectite therapeutic regimen and symptomatic treatment,based on which the treatment group was added with zinc gluconate or zinc glycyrrhetate granules orally.After treatment for 72 h,the clinical efficacy of the two groups was compared,and serum zinc level,immunoglobulin level were checked and compared after treatment for 14 d.Results ① After treatment for 14 d,serum zinc and IgG,IgA,IgM all increased,and zinc,IgG,IgA levels of the treatment group were significantly higher than those of the control group (P＜0.05).② After treatment,diarrhea duration of the treatment group [(6.21±1.5) d] was significantly lower than that of the control group [(7.14±1.8) d],P＜0.05.③ After treatment for 72 h,the overall effective rare and markedly effective rate of the treatment group were both significantly higher than those of the control group (P＜0.05).Conclusion For infantile rotavirus enteritis,zinc supplementation based on regular therapy can improve children's immune function,shorten diarrhea course,and improve the treatment efficiency.