溃疡性结肠炎患者血清P物质、血管活性肠肽及内皮素检测结果分析

摘要

Objective To study change in the levels of gut hormones in patient of ulcerative colitis,and to evaluate the relationship between them.Methods The levels of serum substance P (SP),vasoactive intestinal peptide (VIP),endothelin (ET) were determined by radioimmunity in 53 patients of ulcerative colitis (the study group) and 36 health adults (the control group).Results The levels of serum SP [(1130.75±109.85) μg/ml vs (426.64+89.62)μg/ml],VIP [(124.81±17.61) μg/ml vs (83.26+7.65) μg/ml] and ET [(157.73±28.39) μg/ml vs (88.65+13.76) μg/ml] were all significantly higher in the study group than the control group,with statistically significant difference between the two groups (P＜0.01).Conclusion The levels of SP,VIP and ET increase in patients with ulcerative colitis,which perhaps participate the pathophysiology of ulcerative colitis.%目的 探讨部分胃肠激素在溃疡性结肠炎患者中的变化及两者的相关性.方法 选取武警海南总队医院2002-2011年住院确诊为溃疡性结肠炎患者53例为实验组及同期健康体检者36例为对照组,采用放射免疫法检测其血清SP、VIP和ET水平,分析其与溃疡性结肠炎发病的关系.结果 与正常对照组比较,溃疡性结肠炎患者血清SP [(1130.75±109.85) μg/ml vs (426.64±89.62)μg/ml]、VIP[(124.81±17.61)μg/ml vs(83.26±7.65)μg/ml]和ET [(157.73+28.39)μg/ml vs (88.65+13.76)μg/ml]水平均升高,差异有统计学意义(P.＜0.01).结论 SP、VIP和ET在溃疡性结肠炎患者中均明显升高,可能与溃疡性结肠炎发生、发展相关.