目的 探讨脐血血清中MMP-1及TIMP-1的表达与妊娠期高血压疾病发生及疾病严重程度的相关性.方法 选取43例妊娠期高血压疾病患者为实验组,其中妊娠期高血压18例,轻度子痫前期9例,重度子痫前期16例,同期30例正常晚孕孕妇为对照组.采用酶联免疫吸附试验(ELISA)检测脐血血清中MMP-1及TIMP-1的表达.结果 妊娠期高血压疾病组脐血血清中MMP-1表达低于对照组(P＜0.05),妊娠期高血压组、轻度子痫前期组、重度子痫前期组MMP-1表达逐渐下降,三组间两两比较差异均有统计学意义(P＜0.05),TIMP-1的表达差异无统计学意义(P＞0.05).结论 MMP-1与妊娠期高血压疾病的发生和疾病严重程度之间存在相关性,MMP-1、TIMP-1可能参与妊娠期高血压疾病的发生与发展.%Objective To investigate the relationship between the expression of matrix metallopreteinas es-l (MMP-1), tissue inhibitor of metalloproteinases-1 (TIMP-1) and hypertensive disorders during pregnancy. Methods Forty-three patients with hypertensive disorders during pregnancy were enrolled as the study group, including 18 patients with gestational hypertension, 9 with mild preeclampsia, and 16 with severe preeclampsia. Thirty normal pregnant women were collected as the control group. Enzyme linked immunosorbent assay was used to analyze the expression of MMP-1 and TIMP-1 in umbilicus serum. Results The expression of MMP-1 in the study group was significantly lower than that in the control group (P<0.05). And the more serious was hypertensive disorders during pregnancy, the lower was the expression of MMP-1. There was no statistically significant difference between the two groups in the expression of TIMP-1. Conclusion There was a close relationship between the expression of MMP-1 and hypertensive disorders during pregnancy. MMP-1 and TIMP-1 might play an important role in the development of hypertensive disorders during pregnancy.
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