Objective To investigate the reasons of hypoproteinemia in late trimester of pregnancyand its influences on pregnancy outcome. Methods Ninety pregnant women in late trimester of pregnancy who have had delivery from 2010 to 2011 hadbeen diagnosed with hypoproteinemia after biochemical test. They were divided into pre-eclampsia group (48 cases) and non preeclampsia group (42 cases) according to relevant nosetiology knowledge. Forty-five healthy pregnant women in late trimester of pregnancy were selected as the comtrol group. The top three causes for hypoproteinemia were analyzed. The content of total protein, albumin and prealbumin, and happening situations of fetal growth restriction, placenta early stripping and premature delivery were compared between the three groups. Results The top three causes for hypoproteinemia were preeclampsia (48 cases, 53.33%), hepatic disease (14 cases, 15.56%) and multifetation (12 cases, 13.33%), and the differences between the three groups in content of total protein, albumin and prealbumin were statistically significant (P<0.05). Fetal growth restriction rate, placenta early stripping rate and premature delivery rate in preeclampsia group were significantly higher than those in non preeclampsia group and Control group. Conclusion Primary reasons for hypoproteinemia in late trimester of pregnancy are preeclampsia, liver disease and multiple pregnancy, and hypoproteinemia would increase fetal growth restriction rate, placenta early stripping rate and premature delivery rate significantly.%目的 调查妊娠晚期孕妇低蛋白血症发生的原因及其对妊娠结局的影响.方法 选取2010-2011年间来我院进行分娩的妊娠晚期孕妇90 例,所有入选的孕妇均经过生化学检测确定为低蛋白血症,再根据病因学的相关依据将其分为子痫前期组(48 例)、非子痫前期组(42 例),并选取45 例健康妊娠晚期孕妇进行对照.分析导致妊娠晚期孕妇低蛋白血症发生的排在前3 位的病因,并比较三组间的总蛋白、白蛋白、前白蛋白的含量及三组间胎儿生长受限、胎盘早剥离、早产的发生状况.结果 妊娠晚期孕妇低蛋白血症发生的前三位的病因分别为子痫前期(48 例,53.33%)、肝脏疾病(14 例,15.56%)、多胎妊娠(12 例,13.33%),同时三组间的总蛋白、白蛋白、前白蛋白的含量差异有统计学意义(P<0.05),子痫前期组胎儿生长受限率、胎盘早剥离率、早产率均显著高于非子痫前期组和对照组.结论 妊娠晚期孕妇低蛋白血症发生的主要病因为子痫前期、肝脏疾病、多胎妊娠,且低蛋白血症的发生会显著增加胎儿生长受限率、胎盘早剥离率、早产率.
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