妊娠期血清碱性磷酸酶活性的变化和意义

摘要

目的 探讨女性妊娠各期血清碱性磷酸酶(ALP)活性的变化及临床意义.方法 检测1 362例不同孕期女性的血清ALP活性(实验组)和150例育龄健康未孕女性的血清ALP活性(对照组),对两组数据进行统计学分析.结果 早孕组与对照组比较,ALP活性差异无统计学意义(P＞0.05),中孕组与对照组ALP活性差异有统计学意义(P＜0.05),晚孕组与对照组ALP活性差异有显著统计学意义(P＜0.01).结论 正常妊娠女性的血清ALP活性在中孕后随着孕周的增加而上升,可能和骨代谢、胚胎的发育、母体肝脏代谢和胎盘功能有关系.%Objective To explore the changes and clinical significance of serum alkaline phosphatase (ALP) activity in pregnancy. Methods The serum ALP activity was tested in 150 non-pregnant healthy women (the control group) and 1 362 pregnant women (which were divided into the early pregnancy group, the mid-pregnant group and the late-pregnant group). The data in the two groups were statistically analyzed. Results The ALP activity showed no statistically significant difference between the early pregnancy group and the control group (P>0.05), but statistically significant difference between the mid-pregnant group and the control group (P<0.05) and highly significant difference between the late-pregnant group and the control group (P<0.01). Conclusion The serum ALP activity in normal pregnant women increased with gestational weeks, which may be related with bone metabolism, embryonic development, maternal liver metabolism and placental function.