子宫内膜癌中miRNA与自噬的研究进展

摘要

miRNAs涉及多种生理和病理过程，近期研究其与肿瘤的关系密切，自噬作为细胞在异常环境中维持生存的一种方式近年也备受关注。miR和自噬涉及真核细胞基因表达、发育分化、凋亡、应激等多方面调控，广泛参与免疫防御、肿瘤抑制等多种生理和病理过程，二者与肿瘤的相关研究成为学者争相探究的热点。miR可对自噬多个环节产生调控作用，其调控自噬对肿瘤的促/抑作用为肿瘤的治疗提供新的靶点。该文就miR、自噬在子宫内膜癌的表达以及miR调控自噬对子宫内膜癌等恶性肿瘤发生发展作用的相关研究进行综述。%miRNAs is involved in many physiological and pathological processes, which has been showed to have close relationship with tumor. Autophagy, as a mode of existence for cells in the abnormal environment, has also attracted much attention in recent years. The concepts of miR and autophagy are related to gene expression in eukaryot-ic cells, development and differentiation, apoptosis, stress control, and are involved widely in immune defense, tumor suppression, as well as various physiological and pathological processes. The correlation between miR, autophagy and tumor has become the hot destination of scholars to explore. miR can regulate autophagy in multiple links. It can regu-late the promoting or inhibiting effect of autophagy to tumors and provide a new target for treatment. This article will re-view the expression of miR, autophagy in endometrial carcinoma and functions that miR regulate autophagy in tumors.