老年轻度认知功能障碍相关因素的病例对照研究

摘要

Objective To investigate the related factors of mild cognitive impairment in elderly person. Methods Selected 50 elderly patients with MCI to be the MCI group,and 50 elderly people without MCI in age and sex-matched with MCI to be the control group.At the end of study,the clinical data were compared and analyzed for statistically. Results In the MCI group, the proportion of education≥senior middle school was 20%, the proportion of mental occupation was 26%, and living alone mode was 28%, with a history of stroke was 34%, 58%with hypertension, diabetes accounted for 40%, the SDS score was (44.2±7.3), the level of TG was (2.04±0.41) mmol/L, TC was (6.18±0.81) mmol/L, and that in the con-trol group was 36%, 46%, 12%, 14%, 38%, 22%, (38.5 ± 6.4), (1.53 ± 0.32) mmol/L, (5.22±0.67) mmol/L, these indicators revealed statistically significant difference between the two groups (P<0.05). Conclusion The related factors of MCI in the elderly include living alone, history of stroke, hypertension, diabetes, hyperlipidemia, and depression, whereas high levels of education and mental are the protective factors.%目的：探讨老年轻度认知功能障碍(Mild cognitive impairment，MCI)发生的相关因素。方法50例老年MCI患者纳入MCI组，50例与MCI年龄、性别相匹配的未合并MCI的老年人纳入对照组，比较两组研究对象的临床资料并进行统计学分析。结果 MCI组患者学历在高中以上者比例为20%、职业为脑力劳动者比例为26%、居住方式为独居者比例为28%、有脑卒中病史者占34%、合并高血压者占58%、糖尿病者占40%，SDS评分为(44.2±7.3)分、TG为(2.04±0.41) mmol/L、TC为(6.18±0.81) mmol/L，对照组分别为36%、46%、12%、14%、38%、22%、(38.5±6.4)分、(1.53±0.32) mmol/L、(5.22±0.67) mmol/L，上述指标在两组间差异均有统计学意义(P<0.05)。结论老年MCI的发生与独居、脑卒中病史、合并高血压、糖尿病高脂血症及抑郁症有关，而文化程度高及脑力劳动是其保护性因素。