肠道益生菌联合温生理盐水灌肠改善早产儿喂养不耐受疗效分析

摘要

目的 评估补充肠道益生菌联合温生理盐水灌肠改善早产儿喂养不耐受的效果.方法 将2014年1~12月收治入院且符合纳入标准的早产儿133例,随机分为A组(对照组,不干预,33例)、B组(温生理盐水灌肠,34例)、C组(口服培菲康,35例)和D组(温生理盐水灌肠联合口服培菲康,31例).记录各组早产儿胎粪排尽时间、黄疸消退时间、恢复至出生体重时间、经肠道内喂养每日摄入热卡100 kCal/kg的时间,以评估早产儿是否发生喂养不耐受,并统计各组发生的并发症.结果 在胎粪排尽时间、黄疸消退时间和经肠道内喂养每日摄入热卡100 kCal/kg的时间方面,D组早产儿均低于其他3组,差异均具有显著统计学意义(P<0.05).结论 补充肠道益生菌联合温生理盐水灌肠通便的干预方法安全有效,能显著减少早产儿喂养不耐受的发生.%Objective To investigate the effect of probiotics supplementation combined with warm saline enema on the improvement of feeding intolerance in premature infants.Methods One hundred and thirty-three pre-mature infants,admitted from the January,2014 to December,2014,were randomly divided into four groups:group A (the control group,without intervention,33 cases),group B (warm saline enema,34 cases),group C (probiotics supple-mentation,35 cases),and group D (warm saline enema combined with probiotics supplementation,31 cases).The times for meconium emptying,jaundice disappearance,regaining birth weight,and reaching 100 kcal/kg daily through enteral feeding were recorded in the four groups to evaluate the improvement in feeding tolerance.The complications in every group were calculated.Results The times for meconium emptying,jaundice disappearance,regaining birth weight,and reaching 100 kcal/kg daily through enteral feeding in group D were shorter than those in the other 3 groups,with statistically significant differences (P<0.05).Conclusion Intervention by probiotics supplementation combined with saline enema can reduce significantly the incidence of feeding intolerance in premature infants,which is safe and effective.