食管鳞癌和食管腺癌中VEGF-C和新生淋巴管的表达与病理因素的关系

摘要

Objective To investigate the expression of vascular endothelial growth factor-C (VEGF-C) in esophageal squamous cell carcinoma and esophageal adenocarcinoma, and to analyze its relationship with lymphatic vessels and pathological factors. Methods Fifty-five patients of esophageal squamous cell carcinoma and 5 patients of esophageal adenocarcinoma treated in our hospital from January 2012 to January 2014 were selected. The expres-sion of endothelial cells of the newly-generated lymphatic vessels was labeled by using the trans-membrane like recep-tor protein (Podoplanin), and the expression of VEGF-C and the newly-generated lymphatic vessels in esophageal squamous cell carcinoma and esophageal adenocarcinoma tissues were detected in all patients. Results Expression of VEGF-C was found correlated to pathological types (P<0.05), but not correlated to tumor size, T stage, the degree of differentiation (P>0.05). The expression of VEGF-C and lymphatic microvessel density (LMVD) showed positive correlation (P<0.05). The expressions of VEGF-C and the newly-generated lymphatic vessels were significantly high-er in esophageal adenocarcinoma than esophageal squamous cell carcinoma (P<0.05). VEGF-C high expression group had greater LMVD than VEGF-C low expression group (P<0.05). The survival rate in patients with positive expres-sion of VEGF-C was significantly lower than that in the patients with negative expression of VEGF-C (P<0.05). COX multivariate regression analysis showed that VEGF-C was an independent factor affecting the prognosis of esophageal squamous cell carcinoma and esophageal adenocarcinoma. Conclusion The expression of the newly-generated lym-phatic vessels is significantly higher in esophageal adenocarcinoma than esophageal squamous cell carcinoma, and VEGF-C is an independent risk factor for the prognosis of esophageal squamous cell carcinoma and esophageal adeno-carcinoma.%目的 观察血管内皮生长因子-C (VEGF-C)在食管鳞癌和腺癌组织中的表达,并分析其与新生淋巴管的表达和病理因素的关系.方法 选取2012年1月至2014年1月期间在我院接受治疗的55例食管鳞癌和5例食管腺癌患者,采用跨黏膜样受体蛋白(Podoplanin)对新生淋巴管内皮细胞进行标记,对所有患者的VEGF-C和新生淋巴管在食管鳞癌和腺癌组织中的表达进行检测.结果 VEGF-C的表达与病理类型有关(P<0.05),但与肿瘤大小、T分期、分化程度无关(P>0.05);VEGF-C的表达率与微淋巴管密度(LMVD)呈正相关(P<0.05),食管腺癌VEGF-C和新生淋巴管的表达率明显高于食管鳞癌(P<0.05),VEGF-C的高表达组LMVD大于低表达组(P<0.05);VEGF-C阳性表达者的生存率明显低于阴性者(P<0.05).COX多元回归分析显示,VEGF-C是影响食管鳞癌和腺癌患者预后的独立因素.结论 同分期食管腺癌患者的新生淋巴管的表达明显高于食管鳞癌,VEGF-C是影响食管鳞癌和食管腺癌患者预后的独立因素.